3-Amino-6-methoxypyridazine

Base Information

• Chemical Name: 3-Amino-6-methoxypyridazine
• CAS No.: 7252-84-8
• Molecular Formula: C5H7N3O
• Molecular Weight: 125.13
• Hs Code.: 2933990090
• European Community (EC) Number: 230-670-1
• NSC Number: 73703
• UNII: N3H9A46C5H
• DSSTox Substance ID: DTXSID00222846
• Nikkaji Number: J212.265K
• Wikidata: Q72438944
• Mol file: 7252-84-8.mol

Synonyms:3-Amino-6-methoxypyridazine;7252-84-8;6-Methoxypyridazin-3-amine;3-Pyridazinamine, 6-methoxy-;6-methoxy-3-pyridazinamine;N3H9A46C5H;3-METHOXY-6-AMINOPYRIDAZINE;EINECS 230-670-1;MFCD01646127;NSC-73703;6-METHOXY-PYRIDAZIN-3-YLAMINE;3-Pyridazinamine,6-methoxy-;NSC73703;UNII-N3H9A46C5H;SCHEMBL517891;DTXSID00222846;NSC 73703;AKOS006346710;PB23243;PS-3784;3-amino-6-methoxypyridazine, AldrichCPR;PYRIDAZINE, 3-AMINO-6-METHOXY-;AC-31912;AM804287;SY103873;A9431;CS-0019296;FT-0651150;EN300-138251;Q-102293;Z1201621262

Chemical Property of 3-Amino-6-methoxypyridazine

Chemical Property:

• Vapor Pressure: 3.57E-05mmHg at 25°C
• Melting Point: 108-109℃
• Refractive Index: 1.566
• Boiling Point: 353.5 °C at 760 mmHg
• PKA: 5.84±0.10(Predicted)
• Flash Point: 167.6 °C
• PSA: 61.03000
• Density: 1.224 g/cm³
• LogP: 0.64860
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 125.058911855
• Heavy Atom Count: 9
• Complexity: 88.3

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-6-methoxypyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NN=C(C=C1)N

Technology Process of 3-Amino-6-methoxypyridazine

There total 4 articles about 3-Amino-6-methoxypyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

6-chloro-pyridazin-3-ylamine (5469-69-2) + sodium methylate (124-41-4) → 6-methoxy-3-pyridazinamine (7252-84-8)

Guidance literature:

In methanol; for 72h; Heating;

DOI:10.1002/jhet.5570380530

Reference yield: 76.0%

3-chloro-6-methoxypyridazine (1722-10-7) → 6-methoxy-3-pyridazinamine (7252-84-8) + C10H11N5O2

Guidance literature:

With C₄₆H₇₁Cl₃N₂Pd; ammonia; sodium t-butanolate; In 1,4-dioxane; at 100 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.organomet.6b00830

Reference yield:

Sulfamethoxypyridazine (80-35-3) → 6-methoxy-3-pyridazinamine (7252-84-8)

Guidance literature:

In water; Quantum yield; UV-irradiation;

DOI:10.1016/j.jphotochem.2016.12.008

upstream raw materials:

6-chloro-pyridazin-3-ylamine

sodium methylate

Sulfamethoxypyridazine

3-chloro-6-methoxypyridazine

Downstream raw materials:

Sulfamethoxypyridazine

Refernces

• 1、 Nassar, Rania,Trivella, Aurélien,Mokh, Samia,Al-Iskandarani, Mohamad,Budzinski, Hélène,Mazellier, Patrick. "Photodegradation of sulfamethazine, sulfamethoxypiridazine, amitriptyline, and clomipramine drugs in aqueous media". . p. 176 - 182. Retrieved 2017/01/13.
• 2、 -. "Therapeutically Active Thiazolo-Pyrimidine Derivatives". Paragraph 0242; 0246. . Retrieved 2014/10/29.