2-Ethoxybenzyl alcohol

Base Information

• Chemical Name: 2-Ethoxybenzyl alcohol
• CAS No.: 71672-75-8
• Molecular Formula: C9H12 O2
• Molecular Weight: 152.193
• Hs Code.: 29094980
• European Community (EC) Number: 275-811-8
• DSSTox Substance ID: DTXSID30221903
• Nikkaji Number: J150.121F
• Wikidata: Q83099945
• Mol file: 71672-75-8.mol

Synonyms:2-Ethoxybenzyl alcohol;(2-Ethoxyphenyl)methanol;71672-75-8;Benzenemethanol, 2-ethoxy-;2-Ethoxybenzylalcohol;o-Ethoxybenzyl alcohol;2-Ethoxybenzenemethanol;Ethyl ether of saligenin;BENZYL ALCOHOL, o-ETHOXY-;EINECS 275-811-8;BRN 2555374;Benzenemethanol, 2-ethoxy- (9CI);4-06-00-05897 (Beilstein Handbook Reference);(2-Ethoxyphenyl)methanol #;SCHEMBL695757;2-Ethoxybenzyl alcohol, 98%;DTXSID30221903;MFCD00004616;AKOS000247529;AS-58213;LS-42967;CS-0235340;E0499;FT-0612209;D90532;EN300-155487;A866393

Chemical Property of 2-Ethoxybenzyl alcohol

Chemical Property:

• Appearance/Colour: CLEAR COLOURLESS LIQUID
• Vapor Pressure: 0.00531mmHg at 25°C
• Melting Point: 31-32 °C
• Refractive Index: n20/D 1.532(lit.)
• Boiling Point: 265°C(lit.)
• PKA: 14.43±0.10(Predicted)
• Flash Point: >230°F
• PSA: 29.46000
• Density: 1.074g/mLat 25°C(lit.)
• LogP: 1.57760
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 152.083729621
• Heavy Atom Count: 11
• Complexity: 104

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Ethoxybenzyl alcohol ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1CO
• Uses: 2-Ethoxybenzyl alcohol undergoes acetylation with acetic anhydride over zeolite to yield O-acetylated product. It is also used as pharmaceutical intermediates.

Technology Process of 2-Ethoxybenzyl alcohol

There total 10 articles about 2-Ethoxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-ethoxylbenzaldehyde (613-69-4) → 2-ethoxybenzyl alcohol (71672-75-8)

Guidance literature:

With sodium tetrahydroborate; sodium hydroxide; In water; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2018.08.004

Reference yield:

2-(2-bromoethoxy)benzaldehyde (60633-78-5) → 2-ethoxybenzyl alcohol (71672-75-8)

Guidance literature:

With iron(III) chloride; phenylsilane; sodium methylate; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1039/c8ob02365d

Reference yield:

salicylaldehyde (90-02-8) → 2-ethoxybenzyl alcohol (71672-75-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / ethanol

2: sodium tetrahydroborate / isopropyl alcohol

With sodium tetrahydroborate; potassium carbonate; In ethanol; isopropyl alcohol;

DOI:10.1134/S1070428015010066

upstream raw materials:

2-ethoxylbenzaldehyde

salicylic alcohol

ethyl iodide

salicylaldehyde

Downstream raw materials:

2-ethoxylbenzaldehyde

Br^(1-)*C₂₇H₂₆OP⁽¹⁺⁾

N-(2-ethoxybenzylidene)aniline

N-(2,6-difluorophenyl)-1-{[2-({[2-(ethyloxy)phenyl]methyl}oxy)phenyl]methyl}-1H-pyrazole-3-carboxamide

Refernces

• 1、 Pilli, Ramadevi,Balakrishnan, Venkadesh,Chandrasekaran, Revathi,Rasappan, Ramesh. "Iron-catalyzed protodehalogenation of alkyl and aryl halides using hydrosilanes". supporting information. p. 1749 - 1753. Retrieved 2019/02/20.
• 2、 Cao, Jiangying,Ma, Chunhua,Zang, Jie,Gao, Shuai,Gao, Qianwen,Kong, Xiujie,Yan, Yugang,Liang, Xuewu,Ding, Qin'ge,Zhao, Chunlong,Wang, Binghe,Xu, Wenfang,Zhang, Yingjie. "Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry". . p. 3145 - 3157. Retrieved 2018/06/01.