methyl 3,4-diethoxydihydrocinnamate

Base Information

• Chemical Name: methyl 3,4-diethoxydihydrocinnamate
• CAS No.: 446051-40-7
• Molecular Formula: C₁₄H₂₀O₄
• Molecular Weight: 252.31
• Mol file: 446051-40-7.mol

Synonyms:methyl 3,4-diethoxydihydrocinnamate

Chemical Property of methyl 3,4-diethoxydihydrocinnamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3,4-diethoxydihydrocinnamate

There total 2 articles about methyl 3,4-diethoxydihydrocinnamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2,3-diethoxy-benzaldehyde (24454-82-8) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3,4-diethoxydihydrocinnamate (446051-40-7)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; manganese(III) triacetate dihydrate; silver(I) triflimide; In water; 1,2-dichloro-ethane; at 130 ℃; for 16h; regioselective reaction; Sealed tube;

DOI:10.1021/acs.orglett.9b04433

Reference yield:

→ methyl 3,4-diethoxydihydrocinnamate (446051-40-7)

Guidance literature:

With palladium; acetic acid; Hydrogenation;

DOI:10.1002/ardp.19342720503

Reference yield:

methyl 3,4-diethoxydihydrocinnamate (446051-40-7) → 2-(3,4-diethoxyphenyl)ethylamine (61381-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia

2: sodium hypochlorite

With sodium hypochlorite; ammonia;

DOI:10.1002/ardp.19342720503

upstream raw materials:

2,3-diethoxy-benzaldehyde

acrylic acid methyl ester

Downstream raw materials:

3-(3,4-diethoxy-phenyl)-propionic acid amide

3-(3,4-diethoxy-phenyl)-propionic acid hydrazide

N-(3,4-diethoxyphenethyl)acetamide

2-(3,4-diethoxyphenyl)ethylamine

Refernces