Technology Process of benzyl 4-(2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate
There total 2 articles about benzyl 4-(2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 140 ℃;
for 2.5h;
Inert atmosphere;
DOI:10.1021/jm501175v
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 140 °C / Inert atmosphere
With
potassium carbonate; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm501175v
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 5-chloro-1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one; copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 145 °C / Inert atmosphere
2: trimethylsilyl iodide / dichloromethane / 0.67 h / 0 °C / Inert atmosphere
3: potassium carbonate / N,N-dimethyl-formamide / 9 h / 100 °C / Inert atmosphere
With
copper(l) iodide; trimethylsilyl iodide; 5-chloro-1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one; potassium carbonate;
In
dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm501175v