METHYL A-CHLOROPHENYLACETATE

Base Information

• Chemical Name: METHYL A-CHLOROPHENYLACETATE
• CAS No.: 7476-66-6
• Molecular Formula: C9H9 Cl O2
• Molecular Weight: 184.622
• Hs Code.: 2916399090
• Mol file: 7476-66-6.mol

Synonyms:Aceticacid, chlorophenyl-, methyl ester (6CI,8CI); Methyl 2-chloro-2-phenylacetate;Methyl phenylchloroacetate; Methyl a-chlorophenylacetate; NSC 401796

Chemical Property of METHYL A-CHLOROPHENYLACETATE

Chemical Property:

• Vapor Pressure: 0.0391mmHg at 25°C
• Refractive Index: 1.5230 (estimate)
• Boiling Point: 239.9°C at 760 mmHg
• Flash Point: 108.5°C
• PSA: 26.30000
• Density: 1.195g/cm³
• LogP: 2.13950
• Storage Temp.: Refrigerated.

Purity/Quality:

98.5% ^*data from raw suppliers

Methyl2-chloro-2-phenylacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL A-CHLOROPHENYLACETATE

There total 55 articles about METHYL A-CHLOROPHENYLACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + α-chlorophenylacetyl chloride (2912-62-1) → methyl 2-chloro-2-phenylethanoate (7476-66-6)

Guidance literature:

With triethylamine; at 20 ℃; for 3h;

DOI:10.1055/s-2001-13395

Reference yield: 94.0%

(2-Iodo-1,1-dimethoxy-ethyl)-benzene (62054-83-5) → methyl 2-chloro-2-phenylethanoate (7476-66-6)

Guidance literature:

With chlorine; trimethyl orthoformate; In methanol; at 0 ℃; for 0.166667h;

DOI:10.1039/P19830001483

Reference yield: 93.0%

3,3-dichloro-1,2-diphenylcyclopropene (2570-00-5) + (S)-Methyl mandelate (21210-43-5) → methyl 2-chloro-2-phenylethanoate (7476-66-6) + diphenylcyclopropenone (886-38-4)

Guidance literature:

In dichloromethane; at 23 ℃; for 1.08333h; Inert atmosphere;

DOI:10.1021/ja906520p

upstream raw materials:

methanol

Chloro-phenyl-acetic acid

(RS)-methyl mandelate

α-chlorophenylacetyl chloride

Downstream raw materials:

methyl 2-phenyl-2-(pyrrolidin-1-yl)acetate

methyl 2-phenyl-2-(piperidin-1-yl)acetate

α-morpholine methyl phenylacetate

(3,6-dihydro-2H-[1]pyridyl)-phenyl-acetic acid methyl ester

Refernces

• 1、 Afri, Michal,Gruzman, Arie,Korshin, Edward E.,Leitus, Gregory,Palczewski, Krzysztof,Rothstein, Ayelet,Trifonov, Lena,Viskind, Olga. "Straightforward Access to Terminally Disubstituted Electron-Deficient Alkylidene Cyclopent-2-en-4-ones through Olefination with α-Carbonyl and α-Cyano Secondary Alkyl Sulfones". supporting information. p. 6725 - 6736. Retrieved 2021/12/31.
• 2、 Guo, Hongyu,Zhang, Sheng,Yu, Xiaoqiang,Feng, Xiujuan,Yamamoto, Yoshinori,Bao, Ming. "[3 + 2] Cycloaddition of α-Aryl-α-diazoacetates with Terminal Alkynes via the Cooperative Catalysis of Palladium and Acid". . p. 10789 - 10795. Retrieved 2021/09/08.