Midazolam hydrochloride

Base Information

• Chemical Name: Midazolam hydrochloride
• CAS No.: 59467-96-8
• Molecular Formula: C₁₈H₁₃ClFN₃*ClH
• Molecular Weight: 362.234
• Hs Code.: 2933910000
• European Community (EC) Number: 261-776-6
• NSC Number: 751451
• UNII: W7TTW573JJ
• DSSTox Substance ID: DTXSID8047846
• Wikidata: Q27292444
• NCI Thesaurus Code: C654
• RXCUI: 203128
• ChEMBL ID: CHEMBL1200420
• Mol file: 59467-96-8.mol

Synonyms:Dormicum;Hydrochloride, Midazolam;Maleate, Midazolam;Midazolam;Midazolam Hydrochloride;Midazolam Maleate;Ro 21 3981;Ro 21-3981;Ro 213981;Versed

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Chemical Property of Midazolam hydrochloride

Chemical Property:

• Vapor Pressure: 5.21E-10mmHg at 25°C
• Boiling Point: 496.9 °C at 760 mmHg
• Flash Point: 254.3 °C
• PSA: 30.18000
• LogP: 4.56180
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 361.0548810
• Heavy Atom Count: 24
• Complexity: 471

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F.Cl
• Recent ClinicalTrials: Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents
• Recent EU Clinical Trials: Randomized, controlled trial of the use of intranasal midazolam for the treatment of terminal agitation in palliative care patients
• Recent NIPH Clinical Trials: Open-label Study Midazolam Hydrochloride Oromucosal Solution (MHOS/SHP615) in Children with Status Epilepticus (Convulsive) in a Health Care Setting in Japan
• Uses: Anti-Spasmodic Midazolam Hydrochloride is a sensitive CYP 3A4 probe substrate.

Technology Process of Midazolam hydrochloride

There total 12 articles about Midazolam hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Midazolam (59467-70-8) → midazolam hydrochloride (59467-96-8)

Guidance literature:

Midazolam; With pyrographite; In ethyl acetate; at 30 - 40 ℃; for 1h;

With hydrogenchloride; In ethyl acetate;

Reference yield:

Midazolam (59467-70-8) → 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine dihydrochloride (59467-96-8)

Guidance literature:

With hydrogenchloride; In ethanol; isopropyl alcohol; at -15 - 30 ℃; Inert atmosphere;

Reference yield:

Midazolam (59467-70-8) → 5-aminomethyl-1-[4-chloro-2-(2-fluorobenzoyl)phenyl]-2-methyl-imidazole dihydrochloride (59468-73-4) + midazolam hydrochloride (59467-96-8)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 8h;

upstream raw materials:

8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid

Midazolam

Refernces

• 1、 -. "THERAPEUTIC COMPOUNDS AND FORMULATIONS FOR INTRANASAL DELIVERY". Page/Page column 33. . Retrieved 2016/10/24.
• 2、 -. "Process for the synthesis of 4H-imidazo[1,5-a][1,4]benzodiazepines, in particular midazolam and salts thereof". . . Retrieved 2012/01/06.