N-(2-bromophenyl)-N-methylnitrous amide

Base Information

• Chemical Name: N-(2-bromophenyl)-N-methylnitrous amide
• CAS No.: 17576-86-2
• Molecular Formula: C₇H₇BrN₂O
• Molecular Weight: 215.049
• Mol file: 17576-86-2.mol

Synonyms:N-(2-bromophenyl)-N-methylnitrous amide

Chemical Property of N-(2-bromophenyl)-N-methylnitrous amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-bromophenyl)-N-methylnitrous amide

There total 7 articles about N-(2-bromophenyl)-N-methylnitrous amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-bromo-N,N-dimethylaniline (698-00-0) → N-(2-bromophenyl)-N-methylnitrous amide (17576-86-2)

Guidance literature:

With tert.-butylnitrite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1039/c7gc02775c

Reference yield: 90.0%

2-bromo-N-methylaniline (6832-87-7) → N-(2-bromophenyl)-N-methylnitrous amide (17576-86-2)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 10 ℃; Cooling with ice;

DOI:10.1002/chem.201404506

Reference yield: 89.0%

N-methyl-N-nitrosoaniline (614-00-6) → N-(2-bromophenyl)-N-methylnitrous amide (17576-86-2)

Guidance literature:

With N-Bromosuccinimide; silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; In tert-butyl alcohol; at 30 ℃; for 12h; Reagent/catalyst; Solvent; regioselective reaction; Catalytic behavior;

DOI:10.1039/c8ob00601f

upstream raw materials:

2-bromo-N-methylaniline

2-bromoaniline

2-bromo-N,N-dimethylaniline

N-methyl-N-nitrosoaniline

Downstream raw materials:

2-bromo-N-methylaniline

Refernces

• 1、 Jia, Xiaodong,Li, Pengfei,Shao, Yu,Yuan, Yu,Ji, Honghe,Hou, Wentao,Liu, Xiaofei,Zhang, Xuewen. "Highly selective sp3 C-N bond activation of tertiary anilines modulated by steric and thermodynamic factors". supporting information. p. 5568 - 5574. Retrieved 2017/12/06.