2-BROMO-N-METHYLANILINE 95

Base Information

• Chemical Name: 2-BROMO-N-METHYLANILINE 95
• CAS No.: 6832-87-7
• Molecular Formula: C7H8BrN
• Molecular Weight: 186.051
• Hs Code.: 2921420090
• Mol file: 6832-87-7.mol

Synonyms:Aniline,o-bromo-N-methyl- (7CI,8CI);1-Bromo-2-(methylamino)benzene;2-Bromo-N-methylaniline;N-Methyl-2-bromoaniline;NSC 338420;o-Bromo-N-methylaniline;2-bromo-N-methylbenzenamine;

Chemical Property of 2-BROMO-N-METHYLANILINE 95

Chemical Property:

• Vapor Pressure: 0.0318mmHg at 25°C
• Refractive Index: n20/D 1.6070(lit.)
• Boiling Point: 243.6 °C at 760 mmHg
• PKA: 3.07±0.10(Predicted)
• Flash Point: 101.1 °C
• PSA: 12.03000
• Density: 1.487 g/cm³
• LogP: 2.56380
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

2-Bromo-N-methylaniline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Bromo-N-methylaniline can be used to synthesize benzimidazole derivatives, via one pot N-arylation of amides/cyclic amides in the presence of copper iodide nanoparticles. It can also be used in the synthesis of alkyltelluro-substituted aromatic amines, which can show radical trapping ability.

Technology Process of 2-BROMO-N-METHYLANILINE 95

There total 23 articles about 2-BROMO-N-METHYLANILINE 95 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.7%

2-bromoaniline (615-36-1) + methyl iodide (74-88-4) → 2-bromo-N-methylaniline (6832-87-7)

Guidance literature:

2-bromoaniline; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at 25 ℃; for 3h;

Reference yield: 91.0%

N-(2-bromophenyl)formamide (10113-38-9) → 2-bromo-N-methylaniline (6832-87-7)

Guidance literature:

N-(2-bromophenyl)formamide; With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 24h;

With water; In tetrahydrofuran; diethyl ether;

DOI:10.1002/hc.21111

Reference yield: 90.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-bromoaniline (615-36-1) → 2-bromo-N-methylaniline (6832-87-7)

Guidance literature:

formaldehyd; 2-bromoaniline; With potassium hydroxide; In methanol; at 85 ℃; for 2h; Sealed tube;

With methanol; sodium tetrahydroborate; at 0 - 85 ℃; for 1h; Reagent/catalyst; Sealed tube;

upstream raw materials:

dimethyl sulfate

2-bromoaniline

N-(2-bromophenyl)-N-methylnitrous amide

Methyl benzenesulfonate

Downstream raw materials:

1,2-dimethylindole

1-methyl-3-(4-methylphenyl)-1H-indole

C₁₅H₃₁N₅P₂

C₁₅H₂₇NP₂

Refernces

• 1、 Feng, Xinshu,Huang, Ming. "Effect of the ancillary ligand in N-heterocyclic carbene iridium(III) catalyzed N-alkylation of amines with alcohols". . . Retrieved 2021/06/21.
• 2、 Sarki, Naina,Goyal, Vishakha,Tyagi, Nitin Kumar,Puttaswamy,Narani, Anand,Ray, Anjan,Natte, Kishore. "Simple RuCl3-catalyzed N-Methylation of Amines and Transfer Hydrogenation of Nitroarenes using Methanol". . p. 1722 - 1729. Retrieved 2021/04/19.