1-methyl-3-(4-methylphenyl)-1H-indole

Base Information

• Chemical Name: 1-methyl-3-(4-methylphenyl)-1H-indole
• CAS No.: 154796-08-4
• Molecular Formula: C₁₆H₁₅N
• Molecular Weight: 221.302
• Mol file: 154796-08-4.mol

Synonyms:1-methyl-3-(4-methylphenyl)-1H-indole

Chemical Property of 1-methyl-3-(4-methylphenyl)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 1-methyl-3-(4-methylphenyl)-1H-indole

There total 27 articles about 1-methyl-3-(4-methylphenyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-(4-methylphenyl)-1H-indole (30015-86-2) + methyl iodide (74-88-4) → 1-methyl-3-(4-methylphenyl)-1H-indole (154796-08-4)

Guidance literature:

3-(4-methylphenyl)-1H-indole; With potassium hydroxide; In dimethyl sulfoxide; at 22 ℃; for 1h; Inert atmosphere; Schlenk technique;

methyl iodide; In dimethyl sulfoxide; for 0.5h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c3ob27407a

Reference yield: 86.0%

2-(methyl(phenyl)amino)-1-(p-tolyl)ethan-1-one (79409-00-0) → 1-methyl-3-(4-methylphenyl)-1H-indole (154796-08-4)

Guidance literature:

With ammonium hexafluorophosphate; at 110 ℃; for 24h; Green chemistry;

DOI:10.1039/c4ra11168k

Reference yield: 82.0%

3-chloro-1-methyl-1H-indole (124589-41-9) + para-methylphenylmagnesium bromide (4294-57-9) → 1-methyl-3-(4-methylphenyl)-1H-indole (154796-08-4)

Guidance literature:

With iron(II) triflate; 1,3-bis(2,4,6-trimethylphenyl)-4,5,6,7-tetrahydro-1H-1,3-diazepinium bromide; sodium t-butanolate; In tetrahydrofuran; at 60 ℃; for 16h; Sealed tube; Inert atmosphere;

DOI:10.1039/c8cc01808a

upstream raw materials:

ethanol

2-(methyl(phenyl)amino)-1-(p-tolyl)ethan-1-one

(E)-3-Ureido-but-2-enoic acid ethyl ester

para-bromotoluene

Downstream raw materials:

1-methyl-2-(4-methylphenyl)indole

Refernces

• 1、 Dai, Hui-Xiong,Guo, Zi-Qiong,Ma, Biao,Wang, Xing,Wang, Zhen-Yu,Xu, Hui. "C3-Arylation of indoles with aryl ketonesviaC-C/C-H activations". supporting information. p. 9716 - 9719. Retrieved 2021/09/30.
• 2、 Yao, Guangkai,Zhang, Zhi-Xiang,Zhang, Cheng-Bei,Xu, Han-Hong,Tang, Ri-Yuan. "HFIP-promoted Bischler indole synthesis under microwave irradiation". . . Retrieved 2019/01/03.