N-(2-bromophenyl)formamide

Base Information

• Chemical Name: N-(2-bromophenyl)formamide
• CAS No.: 10113-38-9
• Molecular Formula: C7H6 Br N O
• Molecular Weight: 200.035
• Hs Code.: 2924299090
• European Community (EC) Number: 625-157-8
• DSSTox Substance ID: DTXSID10355876
• Nikkaji Number: J1.134.141A
• Wikidata: Q82134946
• Mol file: 10113-38-9.mol

Synonyms:N-(2-bromophenyl)formamide;10113-38-9;N-2-(Bromophenyl)formamide;Formamide, N-(2-bromophenyl)-;N-2-(BROMOPHENYL)FORMAMIDE 97;N-formyl-o-bromoaniline;2-Bromo-N-formylaniline;2-BROMOFORMANILIDE;N-(2-bromophenyl)form amide;SCHEMBL1116450;DTXSID10355876;N-2-(Bromophenyl)formamide, 97%;AKOS013153805;J-000328

Chemical Property of N-(2-bromophenyl)formamide

Chemical Property:

• Vapor Pressure: 9.44E-05mmHg at 25°C
• Melting Point: 88-92 °C(lit.)
• Refractive Index: 1.633
• Boiling Point: 339°C at 760 mmHg
• Flash Point: 158.8°C
• PSA: 29.10000
• Density: 1.634g/cm³
• LogP: 2.72630
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 198.96328
• Heavy Atom Count: 10
• Complexity: 118

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-2-(Bromophenyl)formamide 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)NC=O)Br

Technology Process of N-(2-bromophenyl)formamide

There total 16 articles about N-(2-bromophenyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

formic acid (64-18-6) + 2-bromoaniline (615-36-1) → N-(2-bromophenyl)formamide (10113-38-9)

Guidance literature:

In toluene; at 110 ℃; for 4h;

Reference yield: 93.0%

2-bromoaniline (615-36-1) + formic acid ethyl ester (109-94-4) → N-(2-bromophenyl)formamide (10113-38-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1021/ol802659m

Reference yield: 88.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 2-bromoaniline (615-36-1) → N-(2-bromophenyl)formamide (10113-38-9)

Guidance literature:

With 1,2,4-Triazole; 8-quinolinol; copper(II) choride dihydrate; at 150 ℃;

DOI:10.1002/cctc.201800609

upstream raw materials:

formic acid

2-bromoaniline

formic acid ethyl ester

trimethyl orthoformate

Downstream raw materials:

2-exo-(2-formamidophenyl)-2-endo-norborneol

2-(2-formamidophenyl)adamantan-2-ol

2-formamidotriphenylmethanol

N-(2-cyanophenyl)formamide

Refernces

• 1、 Vanjari, Rajeshwer,Kumar Allam, Bharat,Nand Singh, Krishna. "Hypervalent iodine catalyzed transamidation of carboxamides with amines". . p. 1691 - 1694. Retrieved 2013.
• 2、 Das, Biswanath,Krishnaiah, Maddeboina,Balasubramanyam,Veeranjaneyulu, Boyapati,Nandan Kumar. "A remarkably simple N-formylation of anilines using polyethylene glycol". . p. 2225 - 2227. Retrieved 2008.
• 3、 Chiang, Kun-Heng,Lu, Shi-Han,Yen, Wan-Ping,Uramaru, Naoto,Tseng, Wei-Siou,Chang, Te-Wei,Wong, Fung Fuh. "Effective Synthesis of N-Arylformamide from α-Halo-N-arylacetamides". . p. 235 - 242. Retrieved 2016.
• 4、 Chen, Ye,Ding, Shi,Du, Siyuan,Hou, Yunlei,Li, Chunyan,Li, Zhen,Liu, Fang,Liu, Ju,Shen, Jiwei,Wang, Huan,Wei, Hao,Wu, Shuang. "Novel 4-phenoxypyridine derivatives bearing imidazole-4-carboxamide and 1,2,4-triazole-3-carboxamide moieties: Design, synthesis and biological evaluation as potent antitumor agents". . . Retrieved 2022/01/26.
• 5、 Wu, Shengfeng,Lei, Xiaofang,Fan, Erkang,Sun, Zhihua. "Thermolysis-Induced Two- or Multicomponent Tandem Reactions Involving Isocyanides and Sulfenic-Acid-Generating Sulfoxides: Access to Diverse Sulfur-Containing Functional Scaffolds". supporting information. p. 522 - 525. Retrieved 2018/02/10.