(E)-1-<4-<(8-amino-3-azaoctamethylene)oxy>phenyl>-2-chloro-1,2-diphenylethylene dihydrobromide

Base Information

• Chemical Name: (E)-1-<4-<(8-amino-3-azaoctamethylene)oxy>phenyl>-2-chloro-1,2-diphenylethylene dihydrobromide
• CAS No.: 95764-38-8
• Molecular Formula: 2BrH*C₂₇H₃₁ClN₂O
• Molecular Weight: 596.833
• Mol file: 95764-38-8.mol

Synonyms:(E)-1-<4-<(8-amino-3-azaoctamethylene)oxy>phenyl>-2-chloro-1,2-diphenylethylene dihydrobromide

Chemical Property of (E)-1-<4-<(8-amino-3-azaoctamethylene)oxy>phenyl>-2-chloro-1,2-diphenylethylene dihydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-<4-<(8-amino-3-azaoctamethylene)oxy>phenyl>-2-chloro-1,2-diphenylethylene dihydrobromide

There total 6 articles about (E)-1-<4-<(8-amino-3-azaoctamethylene)oxy>phenyl>-2-chloro-1,2-diphenylethylene dihydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(E)-1-<4-<<3-aza-8-(benzyloxycarboxamido)octamethylene>oxy>phenyl>-2-chloro-1,2-diphenylethylene (95764-37-7) → (E)-1-<4-<(8-amino-3-azaoctamethylene)oxy>phenyl>-2-chloro-1,2-diphenylethylene dihydrobromide (95764-38-8)

Guidance literature:

With hydrogen bromide; In acetic acid; for 1.5h;

DOI:10.1021/jm00383a010

Reference yield:

(4-(2-bromoethoxy)phenyl)(phenyl)methanone (38459-64-2) → (E)-1-<4-<(8-amino-3-azaoctamethylene)oxy>phenyl>-2-chloro-1,2-diphenylethylene dihydrobromide (95764-38-8)

Guidance literature:

Multi-step reaction with 5 steps

1: diethyl ether; benzene / 1.5 h / Heating

2: 100 percent / 7.8 N HCl / ethanol / 7 h / Heating

3: 64 percent / Cl₂ / CCl₄ / 2.5 h / Heating

4: 75 percent / pentan-1-ol / 5 h / Ambient temperature

5: 82 percent / HBr / acetic acid / 1.5 h

With hydrogenchloride; hydrogen bromide; chlorine; In tetrachloromethane; diethyl ether; ethanol; pentan-1-ol; acetic acid; benzene;

DOI:10.1021/jm00383a010

Reference yield:

(Z/E)-1-<4-(2-bromoethoxy)phenyl>-1,2-diphenyl ethene (95764-34-4,95764-35-5) → (E)-1-<4-<(8-amino-3-azaoctamethylene)oxy>phenyl>-2-chloro-1,2-diphenylethylene dihydrobromide (95764-38-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / Cl₂ / CCl₄ / 2.5 h / Heating

2: 75 percent / pentan-1-ol / 5 h / Ambient temperature

3: 82 percent / HBr / acetic acid / 1.5 h

With hydrogen bromide; chlorine; In tetrachloromethane; pentan-1-ol; acetic acid;

DOI:10.1021/jm00383a010

upstream raw materials:

(E)-1-<4-<<3-aza-8-(benzyloxycarboxamido)octamethylene>oxy>phenyl>-2-chloro-1,2-diphenylethylene

(4-(2-bromoethoxy)phenyl)(phenyl)methanone

(Z/E)-1-<4-(2-bromoethoxy)phenyl>-1,2-diphenyl ethene

1-<4-(2-bromoethoxy)phenyl>-1,2-diphenylethanol

Downstream raw materials:

(E)-1-<4-<<3-aza-8-(chloroacetamido)-3-(chloroacetyl)octamethylene>oxy>phenyl>-2-chloro-1,2-diphenylethylene

Refernces