2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid

Base Information

• Chemical Name: 2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid
• CAS No.: 114315-58-1
• Molecular Formula: C₁₈H₁₇ClO₃
• Molecular Weight: 316.784
• Mol file: 114315-58-1.mol

Synonyms:2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid

Chemical Property of 2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid

There total 1 articles about 2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ketoprofen chloride (59512-44-6,71381-92-5,109718-56-1) + 2-chloro-ethanol (107-07-3) → 2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid (114315-58-1)

Guidance literature:

With sodium hydrogencarbonate; In benzene; at 80 ℃; for 4h;

DOI:10.1134/S1070363219050141

Reference yield:

2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid (114315-58-1) → S-ketoprofen (22161-81-5,22161-86-0) + R-ketoprofen (56105-81-8,22161-86-0)

Guidance literature:

With water; at 40 ℃; for 40h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Candida rugosa lipase, pH 5;

DOI:10.1021/ja00131a006

Reference yield:

2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid (114315-58-1) → S-ketoprofen (22161-81-5,22161-86-0)

Guidance literature:

With lipase OF I; In water; at 37 ℃; for 36h; pH=3;

DOI:10.1016/S0957-4166(01)00017-9

upstream raw materials:

ketoprofen chloride

2-chloro-ethanol

Downstream raw materials:

S-ketoprofen

(R)-ketoprofen chloroethyl ester

R-ketoprofen

Refernces