1-phenyl-5-(3-indolyl)-1,3-pentadiyne

Base Information

• Chemical Name: 1-phenyl-5-(3-indolyl)-1,3-pentadiyne
• CAS No.: 97311-31-4
• Molecular Formula: C₁₉H₁₃N
• Molecular Weight: 255.319
• Mol file: 97311-31-4.mol

Synonyms:1-phenyl-5-(3-indolyl)-1,3-pentadiyne

Chemical Property of 1-phenyl-5-(3-indolyl)-1,3-pentadiyne

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-5-(3-indolyl)-1,3-pentadiyne

There total 2 articles about 1-phenyl-5-(3-indolyl)-1,3-pentadiyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

3-(prop-2-yn-1-yl)-1H-indole (7394-63-0) + 1-Bromo-2-phenylacetylene (932-87-6) → 1-phenyl-5-(3-indolyl)-1,3-pentadiyne (97311-31-4)

Guidance literature:

With hydroxylamine hydrochloride; isobutylamine; copper(l) chloride; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 4h;

Reference yield:

indole (120-72-9) → 1-phenyl-5-(3-indolyl)-1,3-pentadiyne (97311-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) C₂H₅MgBr / 1) ether - benzene, 50 - 60 deg C, 2) 20 deg C, 24 h

2: 35 percent / CuCl, NH₂OH*HCl, isobutylamine / dimethylformamide / 4 h / 20 - 25 °C

With ethylmagnesium bromide; hydroxylamine hydrochloride; isobutylamine; copper(l) chloride; In N,N-dimethyl-formamide;

upstream raw materials:

3-(prop-2-yn-1-yl)-1H-indole

1-Bromo-2-phenylacetylene

indole

Refernces