C₁₆H₁₈FN

Base Information

• Chemical Name: C₁₆H₁₈FN
• CAS No.: 864960-86-1
• Molecular Formula: C₁₆H₁₈FN
• Molecular Weight: 243.324
• Mol file: 864960-86-1.mol

Synonyms:C₁₆H₁₈FN

Chemical Property of C₁₆H₁₈FN

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C₁₆H₁₈FN

There total 1 articles about C₁₆H₁₈FN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Fluorophenylacetyl chloride (459-04-1) → C16H18FN (864960-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane; water / 1 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h

With lithium aluminium tetrahydride; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; water;

Reference yield:

C16H18FN (864960-86-1) → N-methyl-N-[2-(4-fluoro-phenyl)-ethyl]-amine (459-28-9)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol; at 50 ℃;

Reference yield:

C16H18FN (864960-86-1) → 7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-(4-fluorophenyl)-ethyl]-methyl-amide (864961-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / 5%-palladium/activated carbon / methanol / 50 °C

2: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C

With hydrogen; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; methanol;

upstream raw materials:

4-Fluorophenylacetyl chloride

Downstream raw materials:

N-methyl-N-[2-(4-fluoro-phenyl)-ethyl]-amine

5-bromo-thiophene-3-carboxylic acid [2-(4-fluorophenyl)-ethyl]-amide

7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-(4-fluorophenyl)-ethyl]-methyl-amide

7-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-(4-fluoro-2-nitro-phenyl)-ethyl]-methyl-amide

Refernces