4-BroMo-2-hydroxylindan

Base Information

• Chemical Name: 4-BroMo-2-hydroxylindan
• CAS No.: 125141-73-3
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.074
• Mol file: 125141-73-3.mol

Synonyms:4-bromo-2,3-dihydro-1H-inden-2-ol

Chemical Property of 4-BroMo-2-hydroxylindan

Chemical Property:

• Boiling Point: 311.9±42.0 °C(Predicted)
• PKA: 14.37±0.20(Predicted)
• Density: 1.617±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-2,3-dihydro-1H-inden-2-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BroMo-2-hydroxylindan

There total 7 articles about 4-BroMo-2-hydroxylindan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-Dimethyl-2-butene (563-79-1) + hydrated paratoluene sulphonic acid (APTS, 1H2 O) + di-isopropyl ether (108-20-3) + 4-bromo-indene (45738-35-0) → 4-bromo-2,3-dihydro-1H-inden-2-ol (125141-73-3)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; toluene;

Reference yield:

4-bromo-2,3-dihydroinden-1-one (15115-60-3) → 4-bromo-2,3-dihydro-1H-inden-2-ol (125141-73-3)

Guidance literature:

Multi-step reaction with 5 steps

1: ethanol; sodium tetrahydroborate / 1 h / 15 °C

2: toluene-4-sulfonic acid / toluene / 1 h / 120 °C

3: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 12 h / 0 - 15 °C

4: zinc(II) iodide / toluene / 4 h / 0 - 15 °C

5: methanol; sodium tetrahydroborate / 1 h / 0 - 15 °C

With methanol; sodium tetrahydroborate; ethanol; sodium hydrogencarbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; zinc(II) iodide; In dichloromethane; toluene;

Reference yield:

(±)-4-bromo-2,3-dihydro-1H-inden-1-ol (16657-10-6) → 4-bromo-2,3-dihydro-1H-inden-2-ol (125141-73-3)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / 1 h / 120 °C

2: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 12 h / 0 - 15 °C

3: zinc(II) iodide / toluene / 4 h / 0 - 15 °C

4: methanol; sodium tetrahydroborate / 1 h / 0 - 15 °C

With methanol; sodium tetrahydroborate; sodium hydrogencarbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; zinc(II) iodide; In dichloromethane; toluene;

upstream raw materials:

2,3-Dimethyl-2-butene

di-isopropyl ether

4-bromo-indene

4-bromo-2,3-dihydroinden-1-one

Downstream raw materials:

4-Methoxy-indan-2-one

indan-2-ol

Refernces

• 1、 -. "FUSED PYRAZOLE AND IMIDAZOLE BASED COMPOUNDS AND USE THEREOF AS GLI1 INHIBITORS". . . Retrieved 2021/11/20.