Technology Process of 2-{3-[5-(3-hydroxycyclopentyloxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one
There total 8 articles about 2-{3-[5-(3-hydroxycyclopentyloxy)pyrimidin-2-yl]benzyl}-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-[3-(5-hydroxypyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one; 1,3-dihydroxycyclopentane;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
With
di-tert-butyl-diazodicarboxylate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 21h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium phosphate tribasic trihydrate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere
2.1: thionyl chloride / dichloromethane / 3 h / 20 °C
3.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C
4.1: potassium acetate / N,N-dimethyl-formamide / 0.25 h / 70 °C / Inert atmosphere
4.2: 18 h / 70 °C / Inert atmosphere
5.1: water / tetrahydrofuran / 2 h / 20 °C / Cooling with ice
5.2: pH 1
6.1: polymer-bound triphenylphosphine / N,N-dimethyl-formamide / 0.25 h / 20 °C
6.2: 21 h / 20 °C
With
thionyl chloride; potassium phosphate tribasic trihydrate; water; potassium acetate; caesium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C
2.1: potassium acetate / N,N-dimethyl-formamide / 0.25 h / 70 °C / Inert atmosphere
2.2: 18 h / 70 °C / Inert atmosphere
3.1: water / tetrahydrofuran / 2 h / 20 °C / Cooling with ice
3.2: pH 1
4.1: polymer-bound triphenylphosphine / N,N-dimethyl-formamide / 0.25 h / 20 °C
4.2: 21 h / 20 °C
With
water; potassium acetate; caesium carbonate;
In
tetrahydrofuran; N,N-dimethyl-formamide;