Azlocillin

Base Information

• Chemical Name: Azlocillin
• CAS No.: 37091-65-9
• Molecular Formula: C20H22N5NaO6S
• Molecular Weight: 483.48
• Hs Code.: 2942000000
• European Community (EC) Number: 253-347-7,253-348-2
• UNII: HUM6H389W0
• DSSTox Substance ID: DTXSID1022639
• Nikkaji Number: J19.344E
• Wikipedia: Azlocillin
• Wikidata: Q510154
• NCI Thesaurus Code: C293
• Metabolomics Workbench ID: 43299
• ChEMBL ID: CHEMBL1537
• Mol file: 37091-65-9.mol

Synonyms:Azlin;Azlocillin;Azlocillin Sodium;Azlocillin, Sodium;Bay e 6905;Bay-e 6905;Baye 6905;Securopen;Sodium Azlocillin;Sodium, Azlocillin

Chemical Property of Azlocillin

Chemical Property:

• Flash Point: >110°(230°F)
• PSA: 176.28000
• LogP: -0.25410
• Storage Temp.: room temp
• Solubility.: H2O: soluble50mg/mL
• Water Solubility.: Freely soluble in water
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 461.13690464
• Heavy Atom Count: 32
• Complexity: 844

Purity/Quality:

99% ^*data from raw suppliers

Azlocillin sodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 36

MSDS Files:

Useful:

• Canonical SMILES: CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)NC(=O)N4CCNC4=O)C(=O)O)C
• Isomeric SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)NC(=O)N4CCNC4=O)C(=O)O)C
• Uses: Antibacterial;Bacterial transpeptidase inhibitor Azlocillin sodium is a semisynthetic penicillin and is a potent 1-lactam antibiotic. It is often used against Pseudomonas aeruginosa and has been used to develop novel antibiotic quantitation techniques.
• Therapeutic Function: Antibacterial

Technology Process of Azlocillin

There total 1 articles about Azlocillin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

azlocillin (37091-66-0) → azlocillin sodium (37091-65-9)

Guidance literature:

With sodium hydroxide; In water; at 5 - 8 ℃; pH=7-7.6; Concentration;

Reference yield: 85.0%

azlocillin sodium (37091-65-9) → Azlocillin-Dinatriumpenicilloat (73682-18-5)

Guidance literature:

With sodium hydroxide; In water; at 30 ℃; Penase/Leo, pH=6.0;

Reference yield:

azlocillin sodium (37091-65-9) → Azlocillin-Natrium-penilloat (81474-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / 1 n NaOH / H₂O / 30 °C / Penase/Leo, pH=6.0

2: 92 percent / 0.1 n HCl / H₂O / 3 h / Heating

With hydrogenchloride; sodium hydroxide; In water;

upstream raw materials:

azlocillin

Downstream raw materials:

Azlocillin-Dinatriumpenicilloat

Azlocillin-Natrium-penilloat

Refernces

• 1、 -. "A Azlocillin sodium freeze-dried powder preparation method (by machine translation)". Paragraph 0031; 0045; 0046; 0047; 0048; 0049; 0050. . Retrieved 2016/12/12.