Alfentanil

Base Information Edit

Chemical Name:Alfentanil
CAS No.:71195-58-9
Molecular Formula:C21H32N6O3
Molecular Weight:416.523
Hs Code.:
UNII:1N74HM2BS7
DSSTox Substance ID:DTXSID9022570
Nikkaji Number:J330.279B
Wikipedia:Alfentanil
Wikidata:Q176533
NCI Thesaurus Code:C61626
RXCUI:480
Pharos Ligand ID:SZTYDPTRMSYG
Metabolomics Workbench ID:43093
ChEMBL ID:CHEMBL634
Mol file:71195-58-9.mol

Synonyms:Alfenta;Alfentanil;Alfentanil Hydrochloride;Alfentanyl;Fanaxal;Limifen;R 39209;R-39209;R39209;Rapifen

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Alfentanil Edit

Chemical Property:

Melting Point:140.8 °C
Boiling Point:511.8 °C at 760 mmHg
PKA:pKa 6.5 (Uncertain)
Flash Point:263.3 °C
PSA：85.49000
Density:1.22 g/cm³
LogP:1.32180
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:416.25358890
Heavy Atom Count:30
Complexity:614

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCN3C(=O)N(N=N3)CC)COC
Recent ClinicalTrials:Patient-Controlled Sedation in Port Implantation (PACSPI-2)
Recent EU Clinical Trials:Patient-controlled Sedation in Port Implantation (PACSPI 2)- a randomized controlled trial
Uses The low pKa of alfentanil (6.9) results in it being largely unionised at plasma pH, allowing rapid diffusion to the effect site (t1.2keo ~1min) and rapid onset of action despite it being less lipid soluble than other opioids. It does not bind strongly to opioid receptors, and the effect-site concentration also decreases rapidly as plasma concentrations decrease. Alfentanil is metabolised by the hepatic cytochrome P450 isoform CYP3A4. Genetic variability in the activity of this enzyme may result in two- to threefold variations in pharmacokinetic values when given by infusion. Low, medium or high metabolisers have been identified; this has implications for duration of action when prolonged use is contemplated.
Clinical Use Opioid analgesic: Short surgical procedures Intensive care sedation
Drug interactions Potentially hazardous interactions with other drugs Antibacterials: concentration increased by erythromycin; metabolism accelerated by rifampicin. Antidepressants: possible CNS excitation or depression (hypertension or hypotension) in patients also receiving MAOIs (including moclobemide) - avoid; possibly increased sedative effects with tricyclics. Antifungals: metabolism inhibited by fluconazole and ketoconazole (risk of prolonged or delayed respiratory depression); metabolism possibly inhibited by itraconazole; concentration increased by voriconazole, consider reducing alfentanil dose. Antihistamines: increased sedative effects with sedating antihistamines. Antipsychotics: enhanced hypotensive and sedative effects. Antivirals: concentration possibly increased by ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid. Cytotoxics: use crizotinib with caution. Dopaminergics: avoid with selegiline. Sodium oxybate: enhanced effect of sodium oxybate - avoid.

Technology Process of Alfentanil

There total 3 articles about Alfentanil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%