Technology Process of Perezone
There total 8 articles about Perezone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1 h / 25 - 50 °C
2: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 2 h / Inert atmosphere; Reflux
3: ammonium cerium (IV) nitrate / water; acetonitrile / 0.08 h / 0 °C / Inert atmosphere
4: 2,6-dimethylpyridine; lithium iodide / 4 h / 80 °C / Inert atmosphere
5: daicel chiralpak IA / hexane; isopropyl alcohol / Resolution of racemate
With
2,6-dimethylpyridine; triethylsilane; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); ammonium cerium (IV) nitrate; boron trifluoride diethyl etherate; lithium iodide;
In
1,4-dioxane; hexane; dichloromethane; water; isopropyl alcohol; acetonitrile;
DOI:10.1002/anie.201911978
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1 h / 25 - 50 °C
2: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 2 h / Inert atmosphere; Reflux
3: ammonium cerium (IV) nitrate / water; acetonitrile / 0.08 h / 0 °C / Inert atmosphere
4: 2,6-dimethylpyridine; lithium iodide / 4 h / 80 °C / Inert atmosphere
5: daicel chiralpak IA / hexane; isopropyl alcohol / Resolution of racemate
With
2,6-dimethylpyridine; triethylsilane; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); ammonium cerium (IV) nitrate; boron trifluoride diethyl etherate; lithium iodide;
In
1,4-dioxane; hexane; dichloromethane; water; isopropyl alcohol; acetonitrile;
DOI:10.1002/anie.201911978
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 2 h / Inert atmosphere; Reflux
2: ammonium cerium (IV) nitrate / water; acetonitrile / 0.08 h / 0 °C / Inert atmosphere
3: 2,6-dimethylpyridine; lithium iodide / 4 h / 80 °C / Inert atmosphere
4: daicel chiralpak IA / hexane; isopropyl alcohol / Resolution of racemate
With
2,6-dimethylpyridine; triethylsilane; ammonium cerium (IV) nitrate; boron trifluoride diethyl etherate; lithium iodide;
In
hexane; dichloromethane; water; isopropyl alcohol; acetonitrile;
DOI:10.1002/anie.201911978