2-hydroxy-2-(4-methoxyphenyl)-2-phenyl-acetic acid

Base Information

• Chemical Name: 2-hydroxy-2-(4-methoxyphenyl)-2-phenyl-acetic acid
• CAS No.: 4237-50-7
• Molecular Formula: C15H14 O4
• Molecular Weight: 258.274
• Hs Code.: 2918990090
• Mol file: 4237-50-7.mol

Synonyms:Benzilicacid, 4-methoxy- (6CI,7CI,8CI); 4-Methoxybenzilic acid; NSC 28711;p-Methoxybenzilic acid

Chemical Property of 2-hydroxy-2-(4-methoxyphenyl)-2-phenyl-acetic acid

Chemical Property:

• Vapor Pressure: 7.86E-09mmHg at 25°C
• Boiling Point: 448.5°C at 760 mmHg
• Flash Point: 169.9°C
• PSA: 66.76000
• Density: 1.276g/cm³
• LogP: 2.01570

Purity/Quality:

98%min ^*data from raw suppliers

Hydroxy-(4-methoxy-phenyl)-phenyl-acetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Hydroxy-(4-methoxy-phenyl)-phenyl-acetic Acid can be prepared to use as muscarinic M3 receptor antagonists.

Technology Process of 2-hydroxy-2-(4-methoxyphenyl)-2-phenyl-acetic acid

There total 12 articles about 2-hydroxy-2-(4-methoxyphenyl)-2-phenyl-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-Methoxybenzophenone (611-94-9) + carbon dioxide (124-38-9,18923-20-1) → 4-methoxybenzilic acid (4237-50-7)

Guidance literature:

With potassium iodide; In N,N-dimethyl-formamide; Hg pool cathode, platinum plate anode, constant current of 5.0 nA/cm²;

DOI:10.1246/bcsj.58.1723

Reference yield: 94.0%

4-methoxybenzil (22711-21-3) → 4-methoxybenzilic acid (4237-50-7)

Guidance literature:

4-methoxybenzil; With N-benzyl-trimethylammonium hydroxide; In water; at 60 ℃; for 5h;

With hydrogenchloride; In water; pH=3;

Reference yield: 65.0%

α-Hydroxy-4-methoxy-α-phenylbenzeneacetic acid methyl ester (928712-61-2) → (R)-2-hydroxy-2-(4-methoxyphenyl)-2-phenylacetic acid (4237-50-7,73698-07-4)

Guidance literature:

With sodium hydroxide; In methanol; water; at 0 - 20 ℃; for 3h;

DOI:10.1002/chem.201704816

upstream raw materials:

4-methoxybenzil

4-methoxybenzoin

4-Methoxybenzophenone

carbon dioxide

Downstream raw materials:

α-(4-methoxyphenyl)phenylacetic acid

(R)-2-hydroxy-2-(4-methoxyphenyl)-2-phenylacetic acid

4-methoxy-benzilic acid-(2-diethylamino-ethyl ester)

(+/-)-phthalic acid mono-[2-hydroxy-2-(4-methoxy-phenyl)-2-phenyl-ethyl ester]

Refernces

• 1、 Melcher, Michaela-Christina,Iv?i?, Trpimir,Olagnon, Charlotte,Tenten, Christina,Lützen, Arne,Strand, Daniel. "Control of Enantioselectivity in Rhodium(I) Catalysis by Planar Chiral Dibenzo[a,e]cyclooctatetraenes". supporting information. p. 2344 - 2348. Retrieved 2017/12/26.
• 2、 -. "QUINUCLIDINE DERIVATIVES AND THEIR USE AS MUSCARINIC M3 RECEPTOR ANTAGONISTS". Page/Page column 21. . Retrieved 2008/06/13.