Multi-step reaction with 10 steps
1.1: diisobutylaluminium hydride / toluene / 1.5 h / -70 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
2.2: 3.5 h / -70 - 20 °C
3.1: sodium hydride / 0.08 h / 5 °C / Inert atmosphere
3.2: 2.83 h / 20 °C / Inert atmosphere
4.1: (Bis(tri-tert-butylphosphine)palladium(0)) / toluene; tetrahydrofuran / 2 h / 80 °C / Inert atmosphere
5.1: bis[1,1-di(trifluoromethyl)ethoxy][(2,6-diisopropylphenyl)imino](2-methyl-2-phenylpropylidene)molybdenum / toluene / 18 h / 85 °C / Inert atmosphere
6.1: sodium hydroxide; water / ethanol / 2 h / 20 °C
7.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere
8.1: hydrogen; Crabtree's catalyst / dichloromethane / 3.83 h / 20 °C / Inert atmosphere
9.1: dimethylaluminum chloride / dichloromethane; hexane / 3.66 h / -20 - 20 °C / Inert atmosphere
9.2: 0.67 h / Cooling with ice
10.1: triethylamine; dmap / dichloromethane / 6 h / 20 °C / Inert atmosphere
With
dmap; bis[1,1-di(trifluoromethyl)ethoxy][(2,6-diisopropylphenyl)imino](2-methyl-2-phenylpropylidene)molybdenum; Crabtree's catalyst; (Bis(tri-tert-butylphosphine)palladium(0)); water; hydrogen; dimethylaluminum chloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triethylamine; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;