2-Amino-1,2-diphenylethanol

Base Information

• Chemical Name: 2-Amino-1,2-diphenylethanol
• CAS No.: 530-36-9
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.279
• European Community (EC) Number: 635-830-8
• NSC Number: 409505,409502,10778
• DSSTox Substance ID: DTXSID70903251
• Nikkaji Number: J53.962G
• ChEMBL ID: CHEMBL2152533
• Mol file: 530-36-9.mol

Synonyms:2-amino-1,2-diphenylethanol;erythro-2-amino-1,2-diphenylethanol

Chemical Property of 2-Amino-1,2-diphenylethanol

Chemical Property:

• Melting Point: 165℃
• Boiling Point: 374.3°Cat760mmHg
• PKA: 11.70±0.45(Predicted)
• Flash Point: 180.2°C
• PSA: 46.25000
• Density: 1.148g/cm³
• LogP: 3.12030
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 213.115364102
• Heavy Atom Count: 16
• Complexity: 195

Purity/Quality:

98%min ^*data from raw suppliers

2-AMINO-1,2-DIPHENYL-ETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C(C2=CC=CC=C2)O)N

Technology Process of 2-Amino-1,2-diphenylethanol

There total 174 articles about 2-Amino-1,2-diphenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,3-diphenyloxirane (1689-71-0,17619-97-5,25144-18-7,38628-70-5,40102-60-1,1439-07-2) → 2-amino-1,2-diphenylethanol (530-36-9,3764-63-4,13286-63-0,23190-16-1,23190-17-2,23364-44-5,23412-95-5,39664-87-4,88082-66-0)

Guidance literature:

With ammonia; In methanol; at 75 ℃; for 30h;

DOI:10.1039/a803612h

Reference yield: 95.0%

benzilmonoxime (574-15-2,574-16-3,14090-77-8,5351-34-8) → 2-amino-1,2-diphenylethanol (530-36-9,3764-63-4,13286-63-0,23190-16-1,23190-17-2,23364-44-5,23412-95-5,39664-87-4,88082-66-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 18h; under 2280 Torr;

DOI:10.1016/0040-4020(95)00197-G

Reference yield: 94.0%

benzoin oxime (441-38-3) → 2-amino-1,2-diphenylethanol (530-36-9,3764-63-4,13286-63-0,23190-16-1,23190-17-2,23364-44-5,23412-95-5,39664-87-4,88082-66-0)

Guidance literature:

With (pyridine)(tetrahydroborato)zinc; In tetrahydrofuran; for 3h; Heating;

DOI:10.1002/jccs.200500016

upstream raw materials:

ethanol

L-Tartaric acid

threo-1,2-diphenyl-2-aminoethan-1-ol

benzil dioxime

Downstream raw materials:

dichloro-acetic acid-(α'-hydroxy-bibenzyl-α-ylamide)

(1R,2R)-2-amino-1,2-diphenylethane-1-ol

1,2-diphenyl-1,2-ethanediol

(1S,2S)-2-amino-1,2-diphenylethanol

Refernces

• 1、 Marcyk, Paul T.,Jefferies, Latisha R.,AbuSalim, Deyaa I.,Pink, Maren,Baik, Mu-Hyun,Cook, Silas P.. "Stereoinversion of Unactivated Alcohols by Tethered Sulfonamides". supporting information. p. 1727 - 1731. Retrieved 2019/01/21.
• 2、 -. "Chiral morphine quinoline compound preparation method and chiral amino acid preparation method of compound". Paragraph 0105; 0107; 0108; 0110. . Retrieved 2017/12/13.