dicyclohexylamine salt of N-t-butyloxycarbonyl-L-cysteine

Base Information

• Chemical Name: dicyclohexylamine salt of N-t-butyloxycarbonyl-L-cysteine
• CAS No.: 20866-21-1
• Molecular Formula: C₈H₁₅NO₄S*C₁₂H₂₃N
• Molecular Weight: 402.599
• Mol file: 20866-21-1.mol

Synonyms:dicyclohexylamine salt of N-t-butyloxycarbonyl-L-cysteine

Chemical Property of dicyclohexylamine salt of N-t-butyloxycarbonyl-L-cysteine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of dicyclohexylamine salt of N-t-butyloxycarbonyl-L-cysteine

There total 2 articles about dicyclohexylamine salt of N-t-butyloxycarbonyl-L-cysteine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-α-tert-butoxycarbonyl-S-(3-nitro-2-pyridylthio)-L-cysteine (76880-29-0) → dicyclohexylamine salt of N-t-butyloxycarbonyl-L-cysteine (20866-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 1.) 0.1 mol phosphate buffer, 2.) acid / acetone / 2 h / 1.) pH= 8, 2.) pH= 3

2: 1.) tri-n-butylphosphine, water / 1.) acetone, room temperature, 4 h, 2.) ethyl acetate, 0 deg C

With phosphate buffer; tributylphosphine; water; In acetone;

DOI:10.1246/cl.1981.737

Reference yield:

di-t-butoxycarbonyl-L-cystine (10389-65-8) + N-cyclohexyl-cyclohexanamine (101-83-7) → dicyclohexylamine salt of N-t-butyloxycarbonyl-L-cysteine (20866-21-1)

Guidance literature:

With tributylphosphine; water; Yield given. Multistep reaction; 1.) acetone, room temperature, 4 h, 2.) ethyl acetate, 0 deg C;

DOI:10.1246/cl.1981.737

Reference yield:

N-(tert-Butyloxycarbonyl)-L-cysteine (20887-95-0) + dicyclohexylamine salt of N-t-butyloxycarbonyl-L-cysteine (20866-21-1) + N,N-dimethyl-4-hydroxymethylaniline (1703-46-4) + citric acid (77-92-9,906507-37-7) → N-tert-butoxycarbonyl-S-(4-dimethylamino)benzyl-L-cysteine (183121-49-5)

Guidance literature:

With sodium chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; hydrogen bromide;

upstream raw materials:

di-t-butoxycarbonyl-L-cystine

N-cyclohexyl-cyclohexanamine

N-α-tert-butoxycarbonyl-S-(3-nitro-2-pyridylthio)-L-cysteine

Downstream raw materials:

N-tert-butoxycarbonyl-S-(4-dimethylamino)benzyl-L-cysteine

Refernces