4-(DIMETHYLAMINO)BENZYL ALCOHOL

Base Information

• Chemical Name: 4-(DIMETHYLAMINO)BENZYL ALCOHOL
• CAS No.: 1703-46-4
• Molecular Formula: C9H13 N O
• Molecular Weight: 151.208
• Hs Code.: 2922199090
• Mol file: 1703-46-4.mol

Synonyms:Benzylalcohol, p-(dimethylamino)- (6CI,7CI,8CI);4-(Hydroxymethyl)-N,N-dimethylaniline; 4-(N,N-Dimethylamino)benzyl alcohol; 4-Dimethylaminobenzylalcohol; NSC 49744; p-(Dimethylamino)benzyl alcohol

Chemical Property of 4-(DIMETHYLAMINO)BENZYL ALCOHOL

Chemical Property:

• Vapor Pressure: 0.00258mmHg at 25°C
• Melting Point: 69°C
• Refractive Index: 1.5780-1.5820
• Boiling Point: 125-126℃2mm
• PKA: 14.88±0.10(Predicted)
• Flash Point: 138.1°C
• PSA: 23.47000
• Density: 1.07
• LogP: 1.24490
• Storage Temp.: Freezer

Purity/Quality:

98%,99%, ^*data from raw suppliers

(4-(Dimethylamino)phenyl)methanol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(DIMETHYLAMINO)BENZYL ALCOHOL

There total 54 articles about 4-(DIMETHYLAMINO)BENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-dimethylamino-benzaldehyde (100-10-7) → N,N-dimethyl-4-hydroxymethylaniline (1703-46-4)

Guidance literature:

With C₄₈H₄₃ClN₂P₂Ru; potassium tert-butylate; hydrogen; In methanol; at 50 ℃; for 1h; under 3750.38 Torr; Concentration; Reagent/catalyst; Solvent; Temperature; Pressure; Catalytic behavior; Autoclave; Inert atmosphere;

Reference yield: 92.0%

methyl 4-(N,N-dimethylamino)benzoate (1202-25-1) → N,N-dimethyl-4-hydroxymethylaniline (1703-46-4)

Guidance literature:

With HN(CH₂CH₂C₃H₃N₂Mes)2Cl₂; potassium tert-butylate; hydrogen; cobalt(II) chloride; In tetrahydrofuran; at 100 ℃; for 16h; under 45004.5 Torr; Autoclave; Glovebox;

DOI:10.1002/cjoc.201900292

Reference yield: 82.0%

4-dimethylamino-benzaldehyde (100-10-7) + benzylamine (100-46-9) → 4-((benzylamino)methyl)-N,N-dimethylaniline (55096-85-0) + N,N-dimethyl-4-hydroxymethylaniline (1703-46-4)

Guidance literature:

With 4,4'-di-tert-butylbiphenyl; lithium; In tetrahydrofuran; at 25 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.04.054

upstream raw materials:

sodium ethanolate

4-formyl-tri-N-methyl-anilinium; chloride

formaldehyd

N,N-dimethyl-aniline

Downstream raw materials:

N-(4’-(N’,N’-dimethylamino)benzyl)-4-methylaniline

(4-methoxyphenyl)-(4-N,N-dimethylaminophenyl)-methane

N,N'-bis(2-nitrophenyl)methanediamine

4,4'-methylene-bis(N,N-dimethylaniline)

Refernces

• 1、 Jagodzinski, Paul W.,Peticolas, Warner L.. "Resonance enhanced raman identification of the zinc-oxygen bond in a horse liver alcohol dehydrogenase-nicotinamide adenine dinucleotide-aldehyde transient chemical intermediate". . p. 234 - 236. Retrieved 1981.
• 2、 Vilar, Márcio,Navarro, Marcelo. "β-cyclodextrin as inverse phase transfer catalyst on the electrocatalytic hydrogenation of organic compounds in water". . p. 270 - 278. Retrieved 2012.
• 3、 Raya-Barón, álvaro,O?a-Burgos, Pascual,Rodríguez-Diéguez, Antonio,Fernández, Ignacio. "Hydrosilylation of Carbonyl Compounds Catalyzed through a Lithiated Hydrazone Derivative". . p. 2682 - 2689. Retrieved 2018.
• 4、 Shah, Jasmin,Jan, M. Rasul,Muhammad, Mian,Ara, Behisht,Ur Rehman, Ibadat. "Development of an indirect spectrophotometric method for determination of methamidophos insecticide in soil, water and vegetable samples". . p. 311 - 318. Retrieved 2015.
• 5、 Jiang, Yu,Li, Minzhi,Liang, Xu,Mack, John,Wildervanck, Martijn,Nyokong, Tebello,Qin, Mingfeng,Zhu, Weihua. "Lipophilic M(α,α′-OC5H11)8phthalocyanines (M = H2 and Ni(II)): Synthesis, electronic structure, and their utility for highly efficient carbonyl reductions". . p. 18237 - 18246. Retrieved 2015.
• 6、 Liu, Wan-Yi,Xu, Qi-Hai,Ma, Yong-Xiang. "Silica gel promoted solvent-free synthesis of arylcarbinols and ferrocenylcarbinols". . p. 596 - 600. Retrieved 2000.
• 7、 Xi, Zi-Wei,Yang, Lei,Wang, Dan-Yan,Feng, Chuan-Wei,Qin, Yufeng,Shen, Yong-Miao,Pu, Chaodan,Peng, Xiaogang. "Visible Light Induced Reduction and Pinacol Coupling of Aldehydes and Ketones Catalyzed by Core/Shell Quantum Dots". . p. 2474 - 2488. Retrieved 2021/02/05.
• 8、 Delaram, Behnaz,Gholizadeh, Mostafa,Makari, Faezeh,Nokhbeh, Seyed Reza,Salimi, Alireza. "Synthesis, crystal and structural characterization, Hirshfeld surface analysis and DFT calculations of three symmetrical and asymmetrical phosphonium salts". . . Retrieved 2021/07/01.