N,N-dimethyl-4-{[(4-methylphenyl)amino]methyl}aniline

Base Information

• Chemical Name: N,N-dimethyl-4-{[(4-methylphenyl)amino]methyl}aniline
• CAS No.: 127598-85-0
• Molecular Formula: C₁₆H₂₀N₂
• Molecular Weight: 240.348
• Mol file: 127598-85-0.mol

Synonyms:N-(4’-(N’,N’-dimethylamino)benzyl)-4-methylaniline

Chemical Property of N,N-dimethyl-4-{[(4-methylphenyl)amino]methyl}aniline

Chemical Property:

Purity/Quality:

N,N-dimethyl-4-((p-tolylamino)methyl)aniline 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

Useful:

Technology Process of N,N-dimethyl-4-{[(4-methylphenyl)amino]methyl}aniline

There total 8 articles about N,N-dimethyl-4-{[(4-methylphenyl)amino]methyl}aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-(4-dimethylaminobenzylidene)-p-toluidine (17087-90-0,149742-33-6) → N-(4’-(N’,N’-dimethylamino)benzyl)-4-methylaniline (127598-85-0)

Guidance literature:

With phenylsilane; C₄₃H₄₄FeN₂O₄; In dimethyl sulfoxide; at 25 ℃; for 12h; Schlenk technique;

DOI:10.1021/acs.organomet.6b00478

Reference yield: 90.0%

p-toluidine (106-49-0,12221-03-3) + N,N-dimethyl-4-hydroxymethylaniline (1703-46-4) → N-(4’-(N’,N’-dimethylamino)benzyl)-4-methylaniline (127598-85-0)

Guidance literature:

With trans-[Fe(N,N’-bis(diisopropylphosphino)-N''-dimethyl-2,4,6-triamino-1,3,5-triazine)(CO)Br₂]; potassium tert-butylate; In toluene; at 80 ℃; for 16h; Inert atmosphere;

DOI:10.1002/adsc.201600689

Reference yield: 60.0%

C16H18N2O (1260501-57-2) → N-(4’-(N’,N’-dimethylamino)benzyl)-4-methylaniline (127598-85-0)

Guidance literature:

With sodium carbonate; In water; acetonitrile; at 20 ℃; Electrochemical reaction; Green chemistry;

DOI:10.1039/C8SC04337J

upstream raw materials:

p-toluidine

N,N-dimethyl-4-hydroxymethylaniline

N,N-dimethyl-aniline

p-toluidine hydrochloride

Downstream raw materials:

N-(4-dimethylamino-benzyl)-N-p-tolyl-carbamonitrile

(4-amino-phenyl)-(4-dimethylamino-phenyl)-methane

4-<4-(N,N-Dimethylamino)benzyl>-N-methylaniline

p-toluidine

Refernces

• 1、 Wei, Duo,Bruneau-Voisine, Antoine,Dubois, Maxime,Bastin, Stéphanie,Sortais, Jean-Baptiste. "Manganese-Catalyzed Transfer Hydrogenation of Aldimines". . p. 5256 - 5259. Retrieved 2019/04/17.
• 2、 Wei, Duo,Bruneau-Voisine, Antoine,Valyaev, Dmitry A.,Lugan, No?l,Sortais, Jean-Baptiste. "Manganese catalyzed reductive amination of aldehydes using hydrogen as a reductant". supporting information. p. 4302 - 4305. Retrieved 2018/05/03.