C₁₂H₁₀N₂O₅

Base Information

• Chemical Name: C₁₂H₁₀N₂O₅
• CAS No.: 1086764-80-8
• Molecular Formula: C₁₂H₁₀N₂O₅
• Molecular Weight: 262.222
• Mol file: 1086764-80-8.mol

Synonyms:C₁₂H₁₀N₂O₅

Chemical Property of C₁₂H₁₀N₂O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₀N₂O₅

There total 2 articles about C₁₂H₁₀N₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

oxalyl dichloride (79-37-8) + 5-phenyl-hydantoic acid methyl ester (104892-36-6) → C12H10N2O5 (1086764-80-8)

Guidance literature:

In acetonitrile; for 0.833333h; Reflux;

DOI:10.1016/j.tetlet.2012.06.129

Reference yield:

N-phenylparabanic acid (2211-33-8) + methyl chloroacetate (96-34-4) → C12H10N2O5 (1086764-80-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Sonication;

DOI:10.1055/s-2008-1078017

Reference yield: 61.0%

C12H10N2O5 (1086764-80-8) + N-(p-tolyl)-P,P,P-triphenylphosphine imide (2327-67-5) → methyl ((5E)-5-[(4-methylphenyl)imino]-2,4-dioxo-3-phenylimidazolidin-1-yl)acetate (1394129-71-5)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; for 2h; stereoselective reaction; Reflux;

DOI:10.1016/j.tetlet.2012.06.129

upstream raw materials:

N-phenylparabanic acid

methyl chloroacetate

oxalyl dichloride

5-phenyl-hydantoic acid methyl ester

Downstream raw materials:

2-(3-phenylureido)acetic acid

methyl ((5E)-5-[(4-methylphenyl)imino]-2,4-dioxo-3-phenylimidazolidin-1-yl)acetate

methyl ((5E)-5-[(4-bromophenyl)imino]-2,4-dioxo-3-phenylimidazolidin-1-yl)acetate

Refernces

• 1、 Bogolubsky, Andrey V.,Ryabukhin, Sergey V.,Pakhomov, Gennadiy G.,Ostapchuk, Eugeniy N.,Shivanyuk, Alexander N.,Tolmachev, Andrey A.. "A facile synthesis of N-carbamoylamino acids". experimental part. p. 2279 - 2282. Retrieved 2009/05/30.