1-(4'-chlorophenyl)-2-phenyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride

Base Information

• Chemical Name: 1-(4'-chlorophenyl)-2-phenyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride
• CAS No.: 96730-35-7
• Molecular Formula: C₁₅H₁₄ClN₅*ClH
• Molecular Weight: 336.224
• Mol file: 96730-35-7.mol

Synonyms:1-(4'-chlorophenyl)-2-phenyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride

Chemical Property of 1-(4'-chlorophenyl)-2-phenyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4'-chlorophenyl)-2-phenyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride

There total 4 articles about 1-(4'-chlorophenyl)-2-phenyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

benzaldehyde (100-52-7) + 4-chloro-aniline (106-47-8) + N-Cyanoguanidine (127099-85-8,780722-26-1,461-58-5) → 1-(4'-chlorophenyl)-2-phenyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride (96730-35-7)

Guidance literature:

With hydrogenchloride; microwave irradiation;

DOI:10.1016/j.bmcl.2004.12.049

Reference yield: 58.0%

1-(4-chlorophenyl)biguanide hydrochloride (4022-81-5,55307-40-9) + benzaldehyde (100-52-7) → 1-(4'-chlorophenyl)-2-phenyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride (96730-35-7)

Guidance literature:

With hydrogenchloride; Triethyl orthoacetate; In methanol; at 20 ℃;

DOI:10.1081/SCC-120005415

Reference yield:

dicyandiamide (127099-85-8,780722-26-1) + benzaldehyde (100-52-7) + 4-chloro-aniline (106-47-8) → 1-(4'-chlorophenyl)-2-phenyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride (96730-35-7)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 140 ℃; for 0.833333h; Microwave irradiation;

DOI:10.1021/acscombsci.9b00079

upstream raw materials:

p-chloroaniline hydrochloride

benzaldehyde

N-Cyanoguanidine

4-chloro-aniline

Downstream raw materials:

N²-(4-chlorophenyl)-6-phenyl-1,3,5-triazine-2,4-diamine

Refernces

• 1、 Junaid, Ahmad,Lim, Felicia Phei Lin,Tiekink, Edward R. T.,Dolzhenko, Anton V.. "New one-pot synthesis of 1,3,5-triazines: three-component condensation, dimroth rearrangement, and dehydrogenative aromatization". supporting information. p. 548 - 555. Retrieved 2019/06/25.
• 2、 -. "Dihydrofolate reductase inhibitors". Page/Page column 7; 8. . Retrieved 2008/06/13.