8-Hydroxygalangin

Base Information

• Chemical Name: 8-Hydroxygalangin
• CAS No.: 74693-69-9
• Molecular Formula: C₁₅H₁₀O₆
• Molecular Weight: 286.241
• DSSTox Substance ID: DTXSID00225670
• Wikidata: Q83104745
• Metabolomics Workbench ID: 26171
• Mol file: 74693-69-9.mol

Synonyms:8-Hydroxygalangin;3,5,7,8-Tetrahydroxyflavone;BRN 0295943;2-Phenyl-3,5,7,8-tetrahydroxy-4H-1-benzopyran-4-one;74693-69-9;4H-1-Benzopyran-4-one, 2-phenyl-3,5,7,8-tetrahydroxy-;FLAVONE, 3,5,7,8-TETRAHYDROXY-;4H-1-Benzopyran-4-one, 2-phenyl-3,5,7,8-tetrahydroxy- (9CI);DTXSID00225670;LMPK12113088;LS-69040

Chemical Property of 8-Hydroxygalangin

Chemical Property:

• Vapor Pressure: 6.41E-13mmHg at 25°C
• Boiling Point: 554.9°C at 760 mmHg
• Flash Point: 215.2°C
• Density: 1.688g/cm³
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 286.04773803
• Heavy Atom Count: 21
• Complexity: 453

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(C(=O)C3=C(O2)C(=C(C=C3O)O)O)O

Technology Process of 8-Hydroxygalangin

There total 9 articles about 8-Hydroxygalangin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,8-dihydroxy-3,7-dimethoxyflavone (33803-31-5) → 3,5,7,8-tetrahydroxyflavone (74693-69-9)

Guidance literature:

With hydrogen iodide; acetic anhydride;

Reference yield:

5-hydroxy-3,7-dimethoxyflavone (70786-48-0) → 3,5,7,8-tetrahydroxyflavone (74693-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.5 g / KOH, potassium persulphate, pyridine / H₂O

2: 0.3 g / HI / acetic anhydride / 0.5 h / 119 - 120 °C

With pyridine; potassium hydroxide; potassium peroxomonosulphate; hydrogen iodide; In water; acetic anhydride;

Reference yield:

2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone (55317-02-7) → 3,5,7,8-tetrahydroxyflavone (74693-69-9)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium benzoate

2: 4.5 g / K₂CO₃ / acetone / 3 h / Heating

3: 0.5 g / KOH, potassium persulphate, pyridine / H₂O

4: 0.3 g / HI / acetic anhydride / 0.5 h / 119 - 120 °C

With pyridine; sodium benzoate; potassium hydroxide; potassium peroxomonosulphate; hydrogen iodide; potassium carbonate; In water; acetic anhydride; acetone;

upstream raw materials:

5,8-dihydroxy-3,7-dimethoxyflavone

3-hydroxy-5,7,8-trimethoxy-2-phenyl-chromen-4-one

7-hydroxy-3,5,8-trimethoxyflavone

2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone

Downstream raw materials:

platanetin

Refernces