3-Amino-2-bromopyridine

Base Information

• Chemical Name: 3-Amino-2-bromopyridine
• CAS No.: 39856-58-1
• Molecular Formula: C5H5BrN2
• Molecular Weight: 173.012
• Hs Code.: 29333990
• Mol file: 39856-58-1.mol

Synonyms:2-bromopyridin-3-amine;2-bromo-pyridin-3-ylamine;2-Bromo-3-aminopyridine;

Chemical Property of 3-Amino-2-bromopyridine

Chemical Property:

• Appearance/Colour: Light yellow Cryst.
• Vapor Pressure: 0.00182mmHg at 25°C
• Melting Point: 76-80 °C
• Refractive Index: 1.636
• Boiling Point: 292.5 °C at 760 mmHg
• PKA: 1.72±0.10(Predicted)
• Flash Point: 130.7 °C
• PSA: 38.91000
• Density: 1.71 g/cm³
• LogP: 2.00750
• Storage Temp.: Room temperature.
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-2-bromopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, Xn
• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41-36/37/38
• Safety Statements: 26-36/39-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Used in a palladium-catalyzed synthesis of indole systems containing fused medium- and large-ring heterocycles. pyrrole derivatives ahs been prepared using 3-Amino-2-bromopyridine. Used in P-C coupling reaction.

Technology Process of 3-Amino-2-bromopyridine

There total 8 articles about 3-Amino-2-bromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-3-nitropyridine (19755-53-4) → 3-amino-2-bromopyridine (39856-58-1)

Guidance literature:

With iron; ammonium chloride; In tetrahydrofuran; water; at 60 - 70 ℃; for 5h;

Reference yield: 75.0%

2-bromonicotinamide (87674-18-8) → 3-amino-2-bromopyridine (39856-58-1)

Guidance literature:

With sodium hydroxide; bromine; In water; 1) 0.5 hr, rt; 2) 3hr, 80 deg C;

DOI:10.1016/S0040-4020(01)91919-2

Reference yield: 43.0%

pyridin-3-ylamine (462-08-8) → 6-bromopyridine-3-amine (13534-97-9) + 3-amino-2-bromopyridine (39856-58-1) + 2,6-dibromo-3-aminopyridine (39856-57-0)

Guidance literature:

With N-Bromosuccinimide; In methanol; at 20 ℃; for 144h;

DOI:10.1055/s-2001-18070

upstream raw materials:

2-bromo-3-nitropyridine

2-bromonicotinamide

pyridin-3-ylamine

2-amino-3-nitropyridine

Downstream raw materials:

2-chloro-3-aminopyridine

3-aminopyridine-2-carbonitrile

2-Bromo-3-(2-bromoanilino)pyridine

N-(2-bromopyridin-3-yl)-N-methylamine

Refernces

• 1、 -. "NOVEL ANTIMALARIA AGENT CONTAINING HETEROCYCLIC COMPOUND". Page/Page column 63. . Retrieved 2008/06/13.
• 2、 -. "SUBSTITUTED AZACHINAZOLINES HAVING AN ANTIVIRAL ACTION". Page/Page column 22. . Retrieved 2008/06/13.