3-Amino-2-pyridinecarbonitrile

Base Information

• Chemical Name: 3-Amino-2-pyridinecarbonitrile
• CAS No.: 42242-11-5
• Molecular Formula: C₆H₅N₃
• Molecular Weight: 119.126
• Hs Code.: 2933399090
• Mol file: 42242-11-5.mol

Synonyms:3-Amino-2-cyanopyridine;3-Aminopicolinonitrile; 3-Aminopyridine-2-carbonitrile

Chemical Property of 3-Amino-2-pyridinecarbonitrile

Chemical Property:

• Vapor Pressure: 1.3E-05mmHg at 25°C
• Melting Point: 151°C
• Boiling Point: 368.2°Cat760mmHg
• PKA: 0.61±0.10(Predicted)
• Flash Point: 176.5°C
• PSA: 62.70000
• Density: 1.23g/cm³
• LogP: 1.11668

Purity/Quality:

90.0%Min ^*data from raw suppliers

3-Aminopyridine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-2-pyridinecarbonitrile

There total 10 articles about 3-Amino-2-pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-nitropyridine-2-carbonitrile (51315-07-2) → 3-aminopyridine-2-carbonitrile (42242-11-5)

Guidance literature:

With hydrazine hydrate; In ethanol; at 75 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.catcom.2022.106398

Reference yield: 6.0%

2-chloro-3-aminopyridine (6298-19-7) → 3-aminopyridine-2-carbonitrile (42242-11-5)

Guidance literature:

With CuCN; In N,N-dimethyl-formamide; for 72h; Heating;

Reference yield:

3-fluoropicolinonitrile (97509-75-6) → 3-aminopyridine-2-carbonitrile (42242-11-5)

Guidance literature:

With ammonia; In dimethyl sulfoxide; at 70 ℃; for 6h;

upstream raw materials:

3-amino-2-bromopyridine

2-chloro-3-aminopyridine

2-hydroxy-3-nitropyridine

2-bromo-3-nitropyridine

Downstream raw materials:

3-amino-4,6-dichloropicolinonitrile

Refernces

• 1、 -. "SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE". Page/Page column 139. . Retrieved 2019/01/21.
• 2、 -. "Aminopyrimidine derivatives, processes for their preparation, compositions containing them and their use as pharmaceuticals". . . Retrieved 2008/06/13.