4-(2-THIAZOLYL)PHENOL

Base Information

• Chemical Name: 4-(2-THIAZOLYL)PHENOL
• CAS No.: 81015-49-8
• Molecular Formula: C9H7NOS
• Molecular Weight: 177.227
• Hs Code.: 2934100090
• Mol file: 81015-49-8.mol

Synonyms:2-(4-Hydroxyphenyl)thiazole;4-(2-Thiazolyl)phenol;NSC 11890;4-(thiazol-2-yl)phenol;

Chemical Property of 4-(2-THIAZOLYL)PHENOL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 162-165℃
• Refractive Index: 1.644
• Boiling Point: 348.525 °C at 760 mmHg
• Flash Point: 164.582 °C
• PSA: 61.36000
• Density: 1.305 g/cm³
• LogP: 2.51570

Purity/Quality:

98%min ^*data from raw suppliers

4-(2-Thiazolyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-THIAZOLYL)PHENOL

There total 8 articles about 4-(2-THIAZOLYL)PHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(4-methoxyphenyl)-1,3-thiazole (27088-84-2) → 2-(4-hydroxyphenyl) thiazole (81015-49-8)

Guidance literature:

With water; hydrogen bromide; acetic acid; for 24h; Reflux;

DOI:10.1016/j.ejmech.2010.02.005

Reference yield: 29.27%

2-bromo-1,3-thiazole (3034-53-5,215777-74-5) + (p-hydroxyphenyl)boronic acid (71597-85-8) → 2-(4-hydroxyphenyl) thiazole (81015-49-8)

Guidance literature:

With palladium diacetate; sodium carbonate; triphenylphosphine; In water; N,N-dimethyl-formamide; at 100 ℃; for 2h; Inert atmosphere;

Reference yield: 29.0%

2-bromo-1,3-thiazole (3034-53-5,215777-74-5) + p-Iodophenol (540-38-5) → 2-(4-hydroxyphenyl) thiazole (81015-49-8)

Guidance literature:

2-bromo-1,3-thiazole; With chloro-trimethyl-silane; ethylene dibromide; zinc; In tetrahydrofuran; at 20 ℃; for 0.25h;

p-Iodophenol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 24h; Heating;

DOI:10.1055/s-2001-9753

upstream raw materials:

2-(4-methoxyphenyl)-1,3-thiazole

2-bromo-1,3-thiazole

p-Iodophenol

1-bromo-4-methoxy-benzene

Downstream raw materials:

3,4-O-isopropylidene-1,6-di-O-(4-thiazol-2-yl-phenyl)-D-mannitol

(S)-2-<4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>phenyl>thiazole

2-(4-methoxyphenyl)-1,3-thiazole

5-bromo-2-(4-methoxyphenyl)-1,3-thiazole

Refernces

• 1、 -. "NOVEL NUCLEOSIDE PHOSPHORAMIDATE COMPOUND AND USE THEREOF". Paragraph 0084. . Retrieved 2015/11/24.
• 2、 -. "ARYL AMINO ACID DERIVATIVES AS INHIBITORS FOR TREATING INFLAMMATION". Page/Page column 7; 16. . Retrieved 2008/06/13.