1-(4-N-BUTYLPHENYL)-2-(4-METHOXYPHENYL)ACETYLENE

Base Information

• Chemical Name: 1-(4-N-BUTYLPHENYL)-2-(4-METHOXYPHENYL)ACETYLENE
• CAS No.: 35684-12-9
• Molecular Formula: C19H20O
• Molecular Weight: 264.367
• Hs Code.: 2909309090
• Mol file: 35684-12-9.mol

Synonyms:Benzene,1-butyl-4-[(4-methoxyphenyl)ethynyl]- (9CI);p-Butyl-p'-methoxytolane;p-Methoxy-p'-butyltolane;Benzene,1-butyl-4-[2-(4-methoxyphenyl)ethynyl]-;

Chemical Property of 1-(4-N-BUTYLPHENYL)-2-(4-METHOXYPHENYL)ACETYLENE

Chemical Property:

• Appearance/Colour: Crystalline colorless solid
• Vapor Pressure: 5.52E-06mmHg at 25°C
• Melting Point: 40 °C
• Refractive Index: 1.573
• Boiling Point: 391.543 °C at 760 mmHg
• Flash Point: 188.863 °C
• PSA: 9.23000
• Density: 1.043 g/cm³
• LogP: 4.43760

Purity/Quality:

99% ^*data from raw suppliers

1-Butyl-4-[2-(4-methoxyphenyl)ethynyl]benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-N-BUTYLPHENYL)-2-(4-METHOXYPHENYL)ACETYLENE

There total 6 articles about 1-(4-N-BUTYLPHENYL)-2-(4-METHOXYPHENYL)ACETYLENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

para-iodoanisole (696-62-8) + (4-butylphenyl)acetylene (79887-09-5) → 1-(2-(4-butylphenyl)ethynyl)-4-methoxybenzene (35684-12-9)

Guidance literature:

With carbon dioxide; copper(I) oxide; potassium carbonate; In methanol; acetonitrile; at 20 ℃; for 10h; under 760.051 Torr; Irradiation;

DOI:10.1002/cssc.201901813

Reference yield: 78.0%

4-methoxybenzenesulfonyl hydrazide (1950-68-1) + 3-(4-butylphenyl)propiolic acid → 1-(2-(4-butylphenyl)ethynyl)-4-methoxybenzene (35684-12-9)

Guidance literature:

With triphenyl phosphite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In N,N-dimethyl acetamide; at 80 ℃; for 12h;

DOI:10.1039/C8NJ02964D

Reference yield: 72.0%

→ 1-(2-(4-butylphenyl)ethynyl)-4-methoxybenzene (35684-12-9)

Guidance literature:

With potassium carbonate; copper(l) chloride; In dimethyl sulfoxide; at 30 ℃; for 20h; Inert atmosphere; Irradiation; Sealed tube;

upstream raw materials:

4-chloromethoxybenzene

4-n-butylchlorobenzene

Propiolic acid

para-iodoanisole

Downstream raw materials:

trans-4-butyl-4′-methoxystilbene

C₁₉H₃₀B₁₀O

Refernces

• 1、 Shanmugam, Munusamy,Sagadevan, Arunachalam,Charpe, Vaibhav Pramod,Pampana, V. Kishore Kumar,Hwang, Kuo Chu. "Cu2O Nanocrystals-Catalyzed Photoredox Sonogashira Coupling of Terminal Alkynes and Arylhalides Enhanced by CO2". . p. 287 - 292. Retrieved 2019/11/05.
• 2、 Suzaki, Yuji,Kobayashi, Yuka,Tsuchido, Yoshitaka,Osakada, Kohtaro. "Pd-catalyzed Sonogashira coupling in aqueous media. Observation of micelles that contain substrates and catalyst". . p. 106 - 111. Retrieved 2019/01/23.