N-(4-chloro-2-methoxyphenyl)acetamide

Base Information

• Chemical Name: N-(4-chloro-2-methoxyphenyl)acetamide
• CAS No.: 86412-57-9
• Molecular Formula: C₉H₁₀ClNO₂
• Molecular Weight: 199.637
• Mol file: 86412-57-9.mol

Synonyms:N-(4-chloro-2-methoxyphenyl)acetamide

Chemical Property of N-(4-chloro-2-methoxyphenyl)acetamide

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

N-(4-Chloro-2-methoxyphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-(4-Chloro-2-methoxyphenyl)acetamide (cas# 86412-57-9) is a compound useful in organic synthesis.

Technology Process of N-(4-chloro-2-methoxyphenyl)acetamide

There total 11 articles about N-(4-chloro-2-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chloro-o-anisidine (93-50-5) + acetic anhydride (108-24-7) → N-(4-chloro-2-methoxyphenyl)acetamide (86412-57-9)

Guidance literature:

for 1h; Ambient temperature;

DOI:10.1248/cpb.39.572

Reference yield: 93.0%

N-(4-chloro-2-hydroxyphenyl)acetamide (16323-09-4) + dimethyl sulfate (77-78-1) → N-(4-chloro-2-methoxyphenyl)acetamide (86412-57-9)

Guidance literature:

With sodium hydroxide; In water; at 70 - 80 ℃; for 1h;

DOI:10.1007/BF00814133

Reference yield: 73.0%

acetyl chloride (75-36-5) + 4-chloro-m-anisidine (13726-14-2) → N-(4-chloro-2-methoxyphenyl)acetamide (86412-57-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h;

upstream raw materials:

2-methoxyacetanilide

acetic acid-(2,4,N-trichloro-anilide)

N-benzylidene-2-methoxy-aniline

2-Nitroanisole

Downstream raw materials:

bis-(4-acetylamino-5-methoxy-2-nitro-phenyl)-disulfide

4'-Chloro-N-phenyl-o-acetanisidide

Refernces

• 1、 Jiang, Tao-Shan,Wang, Guan-Wu. "Palladium-catalyzed ortho-alkoxylation of anilides via C-H activation". . p. 9504 - 9509,6. Retrieved 2012/12/12.
• 2、 Ishii,Sugiura,Kogusuri,Watanabe,Murakami. "Fischer indolization and its related compounds. XXIV. Fischer indolization of ethyl pyruvate 2-(2-methoxyphenyl)phenylhydrazone". . p. 572 - 578. Retrieved 2007/10/02.