4'-Chloro-N-phenyl-o-acetanisidide

Base Information

• Chemical Name: 4'-Chloro-N-phenyl-o-acetanisidide
• CAS No.: 135055-93-5
• Molecular Formula: C₁₅H₁₄ClNO₂
• Molecular Weight: 275.735
• Mol file: 135055-93-5.mol

Synonyms:4'-Chloro-N-phenyl-o-acetanisidide

Chemical Property of 4'-Chloro-N-phenyl-o-acetanisidide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-Chloro-N-phenyl-o-acetanisidide

There total 5 articles about 4'-Chloro-N-phenyl-o-acetanisidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

bromobenzene (108-86-1,52753-63-6) + N-(4-chloro-2-methoxyphenyl)acetamide (86412-57-9) → 4'-Chloro-N-phenyl-o-acetanisidide (135055-93-5)

Guidance literature:

With copper(I) bromide; potassium carbonate; at 180 - 190 ℃; for 5h;

DOI:10.1248/cpb.39.572

Reference yield: 75.0%

4-Chloro-N-phenyl-o-anisidine (97026-57-8) + acetic anhydride (108-24-7) → 4'-Chloro-N-phenyl-o-acetanisidide (135055-93-5)

Guidance literature:

With pyridine;

DOI:10.1248/cpb.39.572

Reference yield:

2-methoxy-4-chlorobenzoic acid (57479-70-6) → 4'-Chloro-N-phenyl-o-acetanisidide (135055-93-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) diphenylphosphoryl azide, Et₃N / 1) dioxane, 4 h, reflux 2) 6 h, reflux

2: 94 percent / KOH / ethane-1,2-diol / 1.5 h / 160 °C

3: 98 percent / 1 h / Ambient temperature

4: 79 percent / K₂CO₃, Cu₂Br₂ / 5 h / 180 - 190 °C

With copper(I) bromide; potassium hydroxide; diphenylphosphoranyl azide; potassium carbonate; triethylamine; In ethylene glycol;

DOI:10.1248/cpb.39.572

upstream raw materials:

bromobenzene

N-(4-chloro-2-methoxyphenyl)acetamide

4-Chloro-N-phenyl-o-anisidine

acetic anhydride

Refernces