α-Pyrrolidino-β-methyl styrene

Base Information

• Chemical Name: α-Pyrrolidino-β-methyl styrene
• CAS No.: 148932-08-5
• Molecular Formula: C₁₃H₁₇N
• Molecular Weight: 187.285
• Mol file: 148932-08-5.mol

Synonyms:α-Pyrrolidino-β-methyl styrene

Chemical Property of α-Pyrrolidino-β-methyl styrene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-Pyrrolidino-β-methyl styrene

There total 2 articles about α-Pyrrolidino-β-methyl styrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

pyrrolidine (123-75-1) + 1-phenyl-propan-1-one (93-55-0) → α-Pyrrolidino-β-methyl styrene (148932-08-5)

Guidance literature:

With 4 A molecular sieve; boron trifluoride diethyl etherate; In benzene; for 67h; Heating;

Reference yield:

→ α-Pyrrolidino-β-methyl styrene (148932-08-5)

Guidance literature:

Propiophenon, Pyrrolidin/sd. Bzl., p-Toluolsulfonsaeure (Abschleppen d. enstandenen Wassers);

Reference yield: 87.0%

α-Pyrrolidino-β-methyl styrene (148932-08-5) + 1-Bromo-2-butyne (3355-28-0) → 2-methyl-1-phenyl-hex-4-yn-1-one

Guidance literature:

α-Pyrrolidino-β-methyl styrene; 1-Bromo-2-butyne; With N-ethyl-N,N-diisopropylamine; In chloroform; for 12h; Reflux;

With hydrogenchloride; In chloroform; water; at 65 ℃; for 4h;

DOI:10.1021/ol5035047

upstream raw materials:

pyrrolidine

1-phenyl-propan-1-one

Downstream raw materials:

diphenyl N-<2-phenyl-1-(1-pyrrolidinyl)propylidene>phosphoramidate

[1-Phenyl-1-pyrrolidin-1-yl-meth-(Z)-ylidene]-phosphoramidic acid diphenyl ester

3-dimethylamino-2-methyl-1-phenyl-propan-1-one

1-(2-phenylpropyl)pyrrolidine

Refernces

• 1、 Kawai, Nobutaka,Shioiri, Takayuki. "New Methods and Reagents in Organic Synthesis. 34. Diphenyl Phosphorazidate (DPPA) as a 1,3-Dipole. A Simple, Efficient Conversion of Alkyl Phenyl Ketones to 2-Phenylalkanoic Acids". . p. 2564 - 2573. Retrieved 2007/10/02.