Z-ALA-GLY-OME

Base Information

• Chemical Name: Z-ALA-GLY-OME
• CAS No.: 4840-29-3
• Molecular Formula: C14H18 N2 O5
• Molecular Weight: 294.307
• Hs Code.: 2924299090
• NSC Number: 164070
• ChEMBL ID: CHEMBL1464358
• Mol file: 4840-29-3.mol

Synonyms:Glycine,N-(N-carboxy-L-alanyl)-, N-benzyl methyl ester (7CI,8CI); Glycine,N-[N-[(phenylmethoxy)carbonyl]-L-alanyl]-, methyl ester;Benzyloxycarbonyl-L-alanylglycine methyl ester;N-(Benzyloxycarbonyl)alanylglycine methyl ester; NSC 164070

Chemical Property of Z-ALA-GLY-OME

Chemical Property:

• Vapor Pressure: 5.91E-10mmHg at 25°C
• Melting Point: 62-65 °C
• Boiling Point: 495.4°C at 760 mmHg
• PKA: 11.12±0.46(Predicted)
• Flash Point: 253.4°C
• PSA: 93.73000
• Density: 1.209g/cm³
• LogP: 1.37230
• Storage Temp.: 2-8°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 294.12157168
• Heavy Atom Count: 21
• Complexity: 366

Purity/Quality:

99% ^*data from raw suppliers

(S)-Methyl2-(2-(((benzyloxy)carbonyl)amino)propanamido)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)NCC(=O)OC)NC(=O)OCC1=CC=CC=C1

Technology Process of Z-ALA-GLY-OME

There total 21 articles about Z-ALA-GLY-OME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-Cbz-Ala (1142-20-7) + methoxycarbonylmethylamine (616-34-2) → Z-L-Ala-Gly-OMe (4840-29-3)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 4h;

DOI:10.1080/10286020.2014.916283

Reference yield: 79.0%

Z-Ala-OH 2-nitro-4-sulfenyl ester sodium salt (112695-91-7) + methoxycarbonylmethylamine (616-34-2) → Z-L-Ala-Gly-OMe (4840-29-3)

Guidance literature:

In water;

Reference yield: 74.0%

methoxycarbonylmethylamine (616-34-2) + C19H22NO4S(1+)*CH3O4S(1-) → Z-L-Ala-Gly-OMe (4840-29-3)

Guidance literature:

With triethylamine; In chloroform; for 7h; Ambient temperature;

DOI:10.1246/bcsj.60.2409

upstream raw materials:

N-Cbz-Ala

glycine ethyl ester hydrochloride

methoxycarbonylmethylamine

Cbz-Ala-OH*DCHA

Downstream raw materials:

Cys-Ala-Gly-Ala-Tyr-TFA

Cys-Ala-Gly-Tyr-TFA

Boc-Cys(MBzl)-Ala-Gly-Ala-His-OH

Boc-Cys(MBzl)-Ala-Gly-Ala-Tyr-OH

Refernces

• 1、 Pokorna, Aneta,Bobal, Pavel,Oravec, Michal,Rarova, Lucie,Bobalova, Janette,Jampilek, Josef. "Investigation of permeation of theophylline through skin using selected piperazine-2,5-diones". . . Retrieved 2019/02/26.
• 2、 Li, Xue-Zheng,Chen, Gang,Wang, Hai-Feng,Hua, Hui-Ming,Pei, Yue-Hu. "Synthesis and bioactivity of diketopiperazine PJ147 and its derivatives from Gliocladium sp. YUP08". . p. 764 - 769. Retrieved 2014/08/18.