5-Hydroxypyridine-2-carboxylic acid

Base Information

• Chemical Name: 5-Hydroxypyridine-2-carboxylic acid
• CAS No.: 15069-92-8
• Molecular Formula: C6H5NO3
• Molecular Weight: 139.111
• Hs Code.: 29333990
• European Community (EC) Number: 691-371-3
• NSC Number: 109123
• DSSTox Substance ID: DTXSID10934029
• Nikkaji Number: J1.957.165C
• Wikidata: Q72481196
• Mol file: 15069-92-8.mol

Synonyms:5-Hydroxypicolinic acid;15069-92-8;5-hydroxypyridine-2-carboxylic acid;5-Hydroxy-pyridine-2-carboxylic acid;5-HYDROXY-2-PYRIDINECARBOXYLIC ACID;2-PYRIDINECARBOXYLIC ACID, 5-HYDROXY-;MFCD00661309;5-hydroxy-2-pyridine carboxylic acid;NSC109123;5-Hydroxypicolinicacid;SCHEMBL288224;DTXSID10934029;CGRRUFNHHQCLDZ-UHFFFAOYSA-N;BCP26362;5-hydoxy-pyridine-2-carboxylic acid;5-hydroxypicolinic acid, AldrichCPR;BBL021384;CX1286;STK894097;AKOS005144076;AC-5954;CS-W002653;NSC-109123;PB26027;PS-5444;NCGC00339634-01;SY013072;AM20050824;FT-0620496;H1471;EN300-85194;5-Hydroxypyridine-2-carboxylic acid monohydrate;AB01331858-02;AJ-333/25006089;W-205708;F2124-0959

Chemical Property of 5-Hydroxypyridine-2-carboxylic acid

Chemical Property:

• Appearance/Colour: Crystalline solid
• Vapor Pressure: 1.98E-11mmHg at 25°C
• Melting Point: 260-264 °C
• Boiling Point: 616.2 °C at 760 mmHg
• PKA: 1.15±0.50(Predicted)
• Flash Point: 326.5 °C
• PSA: 70.42000
• Density: 1.485 g/cm3
• LogP: 0.48540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Soluble in acetone, dimethyl sulfoxide , ethanol and methanol.
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 139.026943022
• Heavy Atom Count: 10
• Complexity: 137

Purity/Quality:

99% ^*data from raw suppliers

5-hydroxypicolinic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=NC=C1O)C(=O)O
• Uses: Useful synthetic intermediate. Also intermediate for pharmaceutical application. 5-Hydroxypyridine-2-carboxylic acid is a useful synthetic intermediate.

Technology Process of 5-Hydroxypyridine-2-carboxylic acid

There total 14 articles about 5-Hydroxypyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium alginate → 5-hydroxypicolinic acid (15069-92-8) + 4-deoxy-L-erythro-5-hexoseulose uronic acid (91547-65-8)

Guidance literature:

sodium alginate; With sigma alginate lyase; at 37 ℃; for 24h; Enzymatic reaction; Aqueous buffer;

at 30 ℃; for 96h; Aqueous buffer;

With ammonium sulfate; Aqueous buffer;

Reference yield:

5-sulfo-pyridine-2-carboxylic acid (4833-91-4) → 5-hydroxypicolinic acid (15069-92-8)

Guidance literature:

With sodium hydroxide; water; at 220 ℃;

DOI:10.1021/ja01173a506

Reference yield:

3-HYDROXYPYRIDINE (109-00-2) → 5-hydroxypicolinic acid (15069-92-8)

Guidance literature:

With carbon dioxide; potassium carbonate; at 215 ℃; under 27949.3 Torr;

upstream raw materials:

3-HYDROXYPYRIDINE

5-amino-pyridine-2-carboxylic acid

5-methoxypyridine-2-carboxylic acid

5-sulfo-pyridine-2-carboxylic acid

Downstream raw materials:

3-HYDROXYPYRIDINE

2,6-diiodo-3-hydroxypyridine

methyl 5-hydroxypicolinate

5-hydroxypiperidine-2-carboxylic acid

Refernces

• 1、 Schio, Laurent,Lemoine, Guy,Klich, Michel. "A facile route to aryl amines: Nucleophilic substitution of aryl triflates". . p. 1559 - 1562. Retrieved 2007/10/03.