(E)-2',4'-dimethoxy-3-hydroxystilbene

Base Information

• Chemical Name: (E)-2',4'-dimethoxy-3-hydroxystilbene
• CAS No.: 1335242-34-6
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.301
• Mol file: 1335242-34-6.mol

Synonyms:(E)-2',4'-dimethoxy-3-hydroxystilbene

Chemical Property of (E)-2',4'-dimethoxy-3-hydroxystilbene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2',4'-dimethoxy-3-hydroxystilbene

There total 2 articles about (E)-2',4'-dimethoxy-3-hydroxystilbene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.7%

1-iodo-2,4-dimethoxybenzene (20469-63-0) + 3-hydroxystyrene (620-18-8,24979-69-9) → (E)-2',4'-dimethoxy-3-hydroxystilbene (1335242-34-6)

Guidance literature:

With triethanolamine; palladium diacetate; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bmc.2011.07.015

Reference yield:

meta-hydroxybenzaldehyde (100-83-4) → (E)-2',4'-dimethoxy-3-hydroxystilbene (1335242-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere

1.2: 24 h / 25 °C / Inert atmosphere

2.1: triethanolamine; palladium diacetate / 24 h / 100 °C / Inert atmosphere

With triethanolamine; potassium tert-butylate; palladium diacetate; In tetrahydrofuran; 1.2: Wittig reaction / 2.1: Mizoroki-Heck reaction;

DOI:10.1016/j.bmc.2011.07.015

upstream raw materials:

1-iodo-2,4-dimethoxybenzene

3-hydroxystyrene

meta-hydroxybenzaldehyde

Refernces

• 1、 Albert, Sabrina,Horbach, Ralf,Deising, Holger B.,Siewert, Bianka,Csuk, René. "Synthesis and antimicrobial activity of (E) stilbene derivatives". experimental part. p. 5155 - 5166. Retrieved 2011/10/04.