2-Bromo-3-fluoroaniline

Base Information

• Chemical Name: 2-Bromo-3-fluoroaniline
• CAS No.: 111721-75-6
• Molecular Formula: C6H5BrFN
• Molecular Weight: 190.015
• Hs Code.: 29214200
• Mol file: 111721-75-6.mol

Synonyms:2-Bromo-3-fluorophenylamine;

Chemical Property of 2-Bromo-3-fluoroaniline

Chemical Property:

• Vapor Pressure: 0.068mmHg at 25°C
• Melting Point: 32-34 °C
• Refractive Index: 1.597
• Boiling Point: 229.845 °C at 760 mmHg
• PKA: 1.52±0.10(Predicted)
• Flash Point: 92.807 °C
• PSA: 26.02000
• Density: 1.695 g/cm³
• LogP: 2.75160
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-3-fluoroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-36-36/37/38-20/21/22
• Safety Statements: 9-26-36/37-60

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromo-3-fluoroaniline is used as pharmaceutical intermediate.

Technology Process of 2-Bromo-3-fluoroaniline

There total 19 articles about 2-Bromo-3-fluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-bromo-3-fluoronitrobenzene (59255-94-6) → 2-bromo-3-fluoroaniline (111721-75-6)

Guidance literature:

With hydrogen; nickel; In methanol; at 20 ℃; for 5h; under 7500.75 Torr; Solvent; Pressure; Autoclave;

Reference yield: 89.0%

N-(2-bromo-3-fluorophenyl)-2-hydroxy-2-methylpropanamide (1287791-74-5) → 2-bromo-3-fluoroaniline (111721-75-6)

Guidance literature:

With hydrogenchloride; In ethanol; water; Reflux;

DOI:10.1021/jo200406f

Reference yield: 85.0%

N-(2-bromo-3-fluorophenyl)-2,2,2-trifluoroacetamide (118313-91-0) → 2-bromo-3-fluoroaniline (111721-75-6)

Guidance literature:

With sodium hydroxide; In ethanol; for 2h; Reflux;

DOI:10.1021/jo200406f

upstream raw materials:

2-Bromo-3-fluorobenzamide

N-(2-bromo-3-fluorophenyl)-2,2,2-trifluoroacetamide

meta-fluoroaniline

7-fluoro-1H-indole-2,3-dione

Downstream raw materials:

N-(2-bromo-3-fluorophenyl)butyramide

1-bromo-2-fluoro-6-iodobenzene

N-(2-bromo-3-fluorophenyl)cinnamamide

8-bromo-7-fluoroquinolin-2(1H)-one

Refernces

• 1、 -. "Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases". Paragraph 1674. . Retrieved 2015/09/22.
• 2、 -. "COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES". . . Retrieved 2012/04/23.