7-Fluoroisatin

Base Information

• Chemical Name: 7-Fluoroisatin
• CAS No.: 317-20-4
• Molecular Formula: C8H4FNO2
• Molecular Weight: 165.124
• Hs Code.: 29337900
• Mol file: 317-20-4.mol

Synonyms:7-Fluoroindole-1H-2,3-dione;7-fluoroindoline-2,3-dione;

Chemical Property of 7-Fluoroisatin

Chemical Property:

• Melting Point: 192-196 °C
• Refractive Index: 1.56
• PKA: 8.44±0.20(Predicted)
• PSA: 46.17000
• Density: 1.477 g/cm³
• LogP: 1.09850
• Water Solubility.: Sparingly Soluble in water (0.022 g/L)

Purity/Quality:

99% ^*data from raw suppliers

7-Fluoroindoline-2,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 22-43
• Safety Statements: 37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Fluoroisatin is used as the intermediate of cardiovascular, anti-inflammatory and bactericidal drugs.

Technology Process of 7-Fluoroisatin

There total 9 articles about 7-Fluoroisatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

N-(2-fluorophenyl)-2-(hydroxyimino)acetamide (349-24-6,953070-85-4) → 7-fluoro-1H-indole-2,3-dione (317-20-4)

Guidance literature:

With sulfuric acid; at 65 - 80 ℃; for 0.666667h;

Reference yield: 90.0%

N-(2-Fluorophenyl)-2-hydroxyiminoacetamide (349-24-6,953070-85-4) → 7-fluoro-1H-indole-2,3-dione (317-20-4)

Guidance literature:

With sulfuric acid; at 80 ℃; for 2h;

Reference yield: 87.0%

(2-tert-Butoxycarbonylamino-3-fluoro-phenyl)-oxo-acetic acid ethyl ester → 7-fluoro-1H-indole-2,3-dione (317-20-4)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; Heating;

DOI:10.1016/0040-4039(94)85299-5

upstream raw materials:

N-(2-Fluorophenyl)-2-hydroxyiminoacetamide

7-Fluoro-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one

N-(2-fluorophenyl)-2-(hydroxyimino)acetamide

2-Fluoroaniline

Downstream raw materials:

3-fluoroanthranilic acid

(S)-N-(1-phenylpropyl)-8-fluoro-3-methoxy-2-phenylquinoline-4-carboxamide

2-bromo-3-fluorobenzoyl chloride

2-bromo-3-fluoro-benzoic acid

Refernces

• 1、 Aneja, Babita,Khan, Nashrah Sharif,Khan, Parvez,Queen, Aarfa,Hussain, Afzal,Rehman, Md. Tabish,Alajmi, Mohamed F.,El-Seedi, Hesham R.,Ali, Sher,Hassan, Md. Imtaiyaz,Abid, Mohammad. "Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis". . p. 840 - 852. Retrieved 2019/01/04.
• 2、 -. "Synthesis of 7-halo indoles (by machine translation)". Paragraph 0018. . Retrieved 2017/01/12.