2-Amino-3-fluorobenzoic acid

Base Information

• Chemical Name: 2-Amino-3-fluorobenzoic acid
• CAS No.: 825-22-9
• Molecular Formula: C7H6FNO2
• Molecular Weight: 155.129
• Hs Code.: 29223990
• Mol file: 825-22-9.mol

Synonyms:Anthranilicacid, 3-fluoro- (6CI,8CI);3-Fluoroanthranilicacid;Benzoicacid, 2-amino-3-fluoro-;

Chemical Property of 2-Amino-3-fluorobenzoic acid

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Melting Point: 171-172 °C
• Boiling Point: 294.4 °C at 760 mmHg
• PKA: 4.60±0.10(Predicted)
• Flash Point: 131.8 °C
• PSA: 63.32000
• Density: 1.43 g/cm³
• LogP: 1.68730
• Storage Temp.: Room temperature.
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-fluorobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-3-fluorobenzoic acid

There total 14 articles about 2-Amino-3-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

7-fluoro-1H-indole-2,3-dione (317-20-4) → 3-fluoroanthranilic acid (825-22-9)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide; In water; at 30 - 40 ℃; for 2.25h;

DOI:10.15227/orgsyn.079.0196

Reference yield: 92.0%

2-(3-(4-chlorophenyl)-2-methylpropanamido)-3-fluoro-N,N-dimethylbenzamide → 3-(4-chlorophenyl)-2-methylpropanoic acid (1012-17-5) + 3-fluoroanthranilic acid (825-22-9)

Guidance literature:

With hydrogen bromide; at 80 ℃; for 24h; Sealed tube;

DOI:10.1039/c8cc07481j

Reference yield: 91.0%

3-fluoro-2-(3-(4-fluorophenyl)-2-methylpropanamido)-N,N-dimethylbenzamide → 3-(4-fluorophenyl)-2-methylpropanoic acid (22138-73-4) + 3-fluoroanthranilic acid (825-22-9)

Guidance literature:

With hydrogen bromide; at 80 ℃; for 24h; Sealed tube;

DOI:10.1039/c8cc07481j

upstream raw materials:

7-fluoro-1H-indole-2,3-dione

3-fluorophthalic anhydride

N-(2-Fluorophenyl)-2-hydroxyiminoacetamide

2-Fluoroaniline

Downstream raw materials:

2-Fluoroaniline

Refernces

• 1、 Maitrani, Chandan,Phillips, Robert S.. "Substituents effects on activity of kynureninase from Homo sapiens and Pseudomonas fluorescens". . p. 4670 - 4677. Retrieved 2013/07/26.
• 2、 -. "Condensed pyrazole derivatives, process for producing the same and use thereof". . . Retrieved 2008/06/13.