2-Bromo-3-fluorobenzoyl chloride

Base Information

• Chemical Name: 2-Bromo-3-fluorobenzoyl chloride
• CAS No.: 1000339-91-2
• Molecular Formula: C7H3BrClFO
• Molecular Weight: 237.456
• Hs Code.: 2916399090
• Mol file: 1000339-91-2.mol

Synonyms:2-Bromo-3-fluorobenzoyl chloride

Chemical Property of 2-Bromo-3-fluorobenzoyl chloride

Chemical Property:

• PSA: 17.07000
• LogP: 2.96720

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-3-fluorobenzoylchloride 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-3-fluorobenzoyl chloride

There total 5 articles about 2-Bromo-3-fluorobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-bromo-3-fluoro-benzoic acid (132715-69-6) → 2-bromo-3-fluorobenzoyl chloride (1000339-91-2)

Guidance literature:

With thionyl chloride; at 100 ℃;

DOI:10.1016/j.ejmech.2015.10.032

Reference yield:

7-fluoro-1H-indole-2,3-dione (317-20-4) → 2-bromo-3-fluorobenzoyl chloride (1000339-91-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) 10M NaOH 2) 30percent aq. H₂O₂ / 1) 70 deg C, 60 min 2) 70 deg C, 60 min

2: 1) 48percent HBr, NaNO₂ 2) CuBr / 1) water, 1 h, 0 deg C 2) a) 30 min, r.t. b) 90 min, 70 deg C

3: SOCl₂ / CH₂Cl₂ / 1 h / Heating

With sodium hydroxide; thionyl chloride; hydrogen bromide; dihydrogen peroxide; copper(I) bromide; sodium nitrite; In dichloromethane;

Reference yield:

2-Fluoroaniline (348-54-9) → 2-bromo-3-fluorobenzoyl chloride (1000339-91-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / Na₂SO₄, NH₂OH*HCl, conc. HCl / H₂O / 0.17 h / Heating

2: 55 percent / conc. H₂SO₄ / 0.75 h / 70 °C

3: 1) 10M NaOH 2) 30percent aq. H₂O₂ / 1) 70 deg C, 60 min 2) 70 deg C, 60 min

4: 1) 48percent HBr, NaNO₂ 2) CuBr / 1) water, 1 h, 0 deg C 2) a) 30 min, r.t. b) 90 min, 70 deg C

5: SOCl₂ / CH₂Cl₂ / 1 h / Heating

With hydrogenchloride; sodium hydroxide; thionyl chloride; sulfuric acid; hydroxylamine hydrochloride; hydrogen bromide; dihydrogen peroxide; sodium sulfate; copper(I) bromide; sodium nitrite; In dichloromethane; water;

upstream raw materials:

2-bromo-3-fluoro-benzoic acid

7-fluoro-1H-indole-2,3-dione

2-Fluoroaniline

N-(2-Fluorophenyl)-2-hydroxyiminoacetamide

Downstream raw materials:

2-Bromo-3-fluorobenzamide

2-(2-bromo-3-fluorophenyl)acetic acid

2-bromo-3-fluoroaniline

Refernces

• 1、 Walker, James A.,Vickerman, Kevin L.,Humke, Jenna N.,Stanley, Levi M.. "Ni-Catalyzed Alkene Carboacylation via Amide C-N Bond Activation". supporting information. p. 10228 - 10231. Retrieved 2017/08/10.
• 2、 Wertjes, William C.,Wolfe, Lydia C.,Waller, Peter J.,Kalyani, Dipannita. "Nickel or phenanthroline mediated intramolecular arylation of sp 3 C-H bonds using aryl halides". supporting information. p. 5986 - 5989. Retrieved 2014/01/06.