2,6-Dichlorobenzylamine

Base Information

• Chemical Name: 2,6-Dichlorobenzylamine
• CAS No.: 6575-27-5
• Molecular Formula: C7H7Cl2N
• Molecular Weight: 176.045
• Hs Code.: 29214990
• Mol file: 6575-27-5.mol

Synonyms:2,6-Dichlorobenzylamine;Benzylamine,2,6-dichloro- (6CI,7CI,8CI);(2,6-Dichlorophenyl)methanamine;2,6-Dichlorobenzenemethanamine;

Chemical Property of 2,6-Dichlorobenzylamine

Chemical Property:

• Appearance/Colour: Clear pale yellow liquid
• Vapor Pressure: 0.0207mmHg at 25°C
• Melting Point: 40°C
• Refractive Index: 1.557-1.559
• Boiling Point: 251.3 °C at 760 mmHg
• Flash Point: 105.8 °C
• PSA: 26.02000
• Density: 1.32 g/cm³
• LogP: 3.15240
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

(2,6-Dichlorophenyl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 45-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2,6-Dichlorophenyl)methanamine was one of the reactants used in making a library of highly selective and potent G protein-coupled receptor kinase 2 inhibitors.

Technology Process of 2,6-Dichlorobenzylamine

There total 7 articles about 2,6-Dichlorobenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,6-dichlorobenzaldoxime (25185-95-9) → 2,6-dichlorobenzylamine (6575-27-5)

Guidance literature:

With iron oxide; zirconium(IV) chloride; sodium cyanoborohydride; In neat (no solvent); at 75 - 80 ℃; for 1h;

DOI:10.1007/s13738-014-0550-3

Reference yield: 91.0%

2,6-dichlorobenzaldehyde (83-38-5) → 2,6-dichlorobenzylamine (6575-27-5)

Guidance literature:

With N,N'-bis(salicylidene)-1,2-phenylene-diaminocobalt(II); ammonia; hydrogen; In tetrahydrofuran; water; at 120 ℃; for 24h; Autoclave;

DOI:10.1039/c9sc04963k

Reference yield: 88.0%

2,6-dichloro-benzonitrile (1194-65-6) → 2,6-dichlorobenzylamine (6575-27-5)

Guidance literature:

With sodium tetrahydroborate; In water; at 100 ℃; for 1h; pH=5.5;

DOI:10.1002/cctc.201300984

upstream raw materials:

hexamethylenetetramine

2,6-Dichlorobenzyl bromide

2,6-dichlorobenzaldoxime

2,6-dichlorotoluene

Downstream raw materials:

IPRO-2

N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-(2,6-dichlorobenzylamide)

N⁶-(2,6-dichloro-benzyl)-adenosine

2-(2,6-dichlorobenzyl)isoindoline-1,3-dione

Refernces

• 1、 -. "PROCESS FOR PREPARATION OF HALOGENATED BENZYLAMINE AND INTERMEDIATES THEROF". Page/Page column 20. . Retrieved 2020/08/13.
• 2、 Sadighnia, Leila,Zeynizadeh, Behzad,Karami, Shiva,Abdollahi, Mohammad. "Nano-Fe3O4@SiO2-SO3H: A magnetic, reusable solid-acid catalyst for solvent-free reduction of oximes to amines with the NaBH3CN/ZrCl4 system". . p. 535 - 542. Retrieved 2019/01/04.