2-(Aminomethyl)phenol

Base Information

• Chemical Name: 2-(Aminomethyl)phenol
• CAS No.: 932-30-9
• Molecular Formula: C7H9 N O
• Molecular Weight: 123.155
• Hs Code.: 29222990
• European Community (EC) Number: 213-249-7,256-534-1
• NSC Number: 127870
• UNII: 696R5N4NRM
• DSSTox Substance ID: DTXSID70902921
• Nikkaji Number: J298.514D
• Wikipedia: 2-Hydroxybenzylamine
• Metabolomics Workbench ID: 155131
• ChEMBL ID: CHEMBL155572
• Mol file: 932-30-9.mol

Synonyms:2-(aminomethyl)phenol;2-hydroxybenzylamine

Chemical Property of 2-(Aminomethyl)phenol

Chemical Property:

• Appearance/Colour: COA
• Vapor Pressure: 0.0188mmHg at 25°C
• Melting Point: 127-131 ºC
• Boiling Point: 245°Cat760mmHg
• PKA: 8.63±0.35(Predicted)
• Flash Point: 102°C
• PSA: 46.25000
• Density: 1.141g/cm³
• LogP: 1.55120
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Chloroform (Slightly), Methanol (Very Slightly, Heated)
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 123.068413911
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

99% ^*data from raw suppliers

2-Hydroxybenzylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CN)O
• Recent ClinicalTrials: 2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)
• Uses: A potent γ-ketoaldehyde scavenger that has been shown to protects cardiac sodium channel (NaV1.5) from oxidant-induced inactivation

Technology Process of 2-(Aminomethyl)phenol

There total 37 articles about 2-(Aminomethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

salicylonitrile (611-20-1) → 2-Hydroxybenzylamine (932-30-9)

Guidance literature:

Reference yield: 96.0%

salicylaldehyde-oxime (94-67-7) → 2-Hydroxybenzylamine (932-30-9)

Guidance literature:

With (pyridine)(tetrahydroborato)zinc; In tetrahydrofuran; for 0.5h; Heating;

DOI:10.1002/jccs.200500016

Reference yield: 78.0%

(R)-N-(2-hydroxybenzyl)-2-methylpropane-2-sulfinamide (918885-51-5) → 2-Hydroxybenzylamine (932-30-9)

Guidance literature:

With water; iodine; In tetrahydrofuran; at 50 ℃;

DOI:10.1039/c4cc00958d

upstream raw materials:

salicylonitrile

3,4-dihydro-2H-benzo[e][1,3]oxazin-2-one

salicylaldazine

(E)-2-hydroxylbenzaldehyde oxime

Downstream raw materials:

N-(2-hydroxybenzyl)benzamide

6-(2-hydroxybenzylamino)purine

5,6-benzocyclophosphamide

N-<1-Methyl-3-hydroxy-buten-(2)-yliden>-salicylamin

Refernces

• 1、 Chen, Lina,Ding, Yingying,Jiao, Qingcai,Liu, Junzhong,Yu, Jinhai,Zhang, Hongjuan,Zong, Weilu. "Fabrication of ω-Transaminase@Metal-Organic Framework Biocomposites for Efficiently Synthesizing Benzylamines and Pyridylmethylamines". . . Retrieved 2021/11/05.
• 2、 Fan, Xiaomeng,Gao, Jin,Gao, Mingxia,Jia, Xiuquan,Ma, Jiping,Xu, Jie. "Self-regulated catalysis for the selective synthesis of primary amines from carbonyl compounds". supporting information. p. 7115 - 7121. Retrieved 2021/09/28.