(R)-N-(2-hydroxybenzyl)-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: (R)-N-(2-hydroxybenzyl)-2-methylpropane-2-sulfinamide
• CAS No.: 918885-51-5
• Molecular Formula: C₁₁H₁₇NO₂S
• Molecular Weight: 227.327
• Mol file: 918885-51-5.mol

Synonyms:(R)-N-(2-hydroxybenzyl)-2-methylpropane-2-sulfinamide

Chemical Property of (R)-N-(2-hydroxybenzyl)-2-methylpropane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(2-hydroxybenzyl)-2-methylpropane-2-sulfinamide

There total 3 articles about (R)-N-(2-hydroxybenzyl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-methyl-N-(2-hydroxybenzylidene)propane-2-sulfinamide → (R)-N-(2-hydroxybenzyl)-2-methylpropane-2-sulfinamide (918885-51-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h;

DOI:10.1021/ol062633+

Reference yield:

2-methyl-benzyl alcohol (89-95-2) → (R)-N-(2-hydroxybenzyl)-2-methylpropane-2-sulfinamide (918885-51-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Ti(O-i-Pr)4 / toluene / Heating

2: NaBH₄ / methanol / 0.5 h / 0 °C

With titanium(IV) isopropylate; sodium tetrahydroborate; In methanol; toluene;

DOI:10.1021/ol062633+

Reference yield:

salicylaldehyde (90-02-8) → (R)-N-(2-hydroxybenzyl)-2-methylpropane-2-sulfinamide (918885-51-5)

Guidance literature:

Multi-step reaction with 2 steps

1: titanium(IV) isopropylate / dichloromethane / 24 h / 20 °C

2: sodium tetrahydroborate / methanol / 2 h / Cooling with ice

With titanium(IV) isopropylate; sodium tetrahydroborate; In methanol; dichloromethane;

DOI:10.1016/j.tetlet.2015.12.090

upstream raw materials:

2-methyl-benzyl alcohol

salicylaldehyde

Downstream raw materials:

2-Hydroxybenzylamine

Refernces

• 1、 Zhang, Zhiguo,Rooshenas, Parham,Hausmann, Heike,Schreiner, Peter R.. "Asymmetric transfer hydrogenation of ketimines with trichlorosilane: Structural studies". experimental part. p. 1531 - 1544. Retrieved 2009/12/09.