2-BROMOBENZYLAMINE

Base Information

• Chemical Name: 2-BROMOBENZYLAMINE
• CAS No.: 3959-05-5
• Molecular Formula: C7H8 Br N
• Molecular Weight: 186.051
• Hs Code.: 29214200
• Mol file: 3959-05-5.mol

Synonyms:Benzylamine,o-bromo- (7CI,8CI); 2-Bromobenzenemethanamine; 2-Bromobenzylamine; NSC 338405;o-Bromobenzylamine

Chemical Property of 2-BROMOBENZYLAMINE

Chemical Property:

• Appearance/Colour: Clear slightly yellow liquid
• Vapor Pressure: 0.0321mmHg at 25°C
• Melting Point: 36 °C
• Refractive Index: 1.5875-1.591
• Boiling Point: 243.5°Cat760mmHg
• PKA: 8.52±0.10(Predicted)
• Flash Point: 101°C
• PSA: 26.02000
• Density: 1.481g/cm³
• LogP: 2.60810
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive
• Water Solubility.: Insoluble in Water. Soluble in Alcohol and Ether.

Purity/Quality:

96% 1H NMR ^*data from raw suppliers

2-Bromobenzylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C,Xi
• Statements: 34-21/22
• Safety Statements: 45-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Pharmaceutical intermediates. As intermediate in organic synthesis.

Technology Process of 2-BROMOBENZYLAMINE

There total 19 articles about 2-BROMOBENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ortho-bromobenzaldehyde (6630-33-7) → 2-bromobenzylamine (3959-05-5)

Guidance literature:

With [pentamethylcyclopentadienyl*Ir(N-phenyl-2-pyridinecarboxamidate)Cl]; ammonium formate; In methanol; at 37 ℃; for 15h; chemoselective reaction;

DOI:10.1016/j.tetlet.2020.152196

Reference yield: 94.0%

o-cyanobromobenzene (2042-37-7) → 2-bromobenzylamine (3959-05-5)

Guidance literature:

With lithium borohydride; diisopropopylaminoborane; In tetrahydrofuran; at 25 ℃; for 5h;

DOI:10.1021/jo8023329

Reference yield: 93.0%

o-bromobenzyl azide (126799-87-9) → 2-bromobenzylamine (3959-05-5)

Guidance literature:

With zinc; In methanol; at 20 ℃; for 3h;

DOI:10.3184/030823407X215627

upstream raw materials:

Benzeneacetamide

1-Bromo-2-bromomethyl-benzene

2-bromobenzaldehyde oxime

bromine

Downstream raw materials:

1-(2-bromobenzyl)-3-phenyl-thiourea

N-(2-Brombenzyl)pivalinsaeureamid

o-cyanobromobenzene

(2,2-bis-phenylsulfanyl-vinyl)-(2-bromo-benzyl)-amine

Refernces

• 1、 Beller, Matthias,Chandrashekhar, Vishwas G.,Gawande, Manoj B.,Jagadeesh, Rajenahally V.,Kalevaru, Narayana V.,Kamer, Paul C. J.,Senthamarai, Thirusangumurugan,Zbo?il, Radek. "Ultra-small cobalt nanoparticles from molecularly-defined Co-salen complexes for catalytic synthesis of amines". . p. 2973 - 2981. Retrieved 2020/03/27.
• 2、 Membrat, Romain,Vasseur, Alexandre,Moraleda, Delphine,Michaud-Chevallier, Sabine,Martinez, Alexandre,Giordano, Laurent,Nuel, Didier. "Platinum-(phosphinito-phosphinous acid) complexes as bi-talented catalysts for oxidative fragmentation of piperidinols: An entry to primary amines". . p. 37825 - 37829. Retrieved 2019/12/03.