AMINO-(2-CHLORO-PHENYL)-ACETIC ACID

Base Information

• Chemical Name: AMINO-(2-CHLORO-PHENYL)-ACETIC ACID
• CAS No.: 88744-36-9
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Hs Code.: 29224985
• Mol file: 88744-36-9.mol

Synonyms:Glycine,2-(o-chlorophenyl)- (7CI);2-(2-Chlorophenyl)glycine;2-Amino-2-(2-chlorophenyl)acetic acid;NSC154921;(R,S)-a-Amino-a-(2-chlorophenyl)aceticacid;

Chemical Property of AMINO-(2-CHLORO-PHENYL)-ACETIC ACID

Chemical Property:

• Melting Point: 218-220 °C (decomp)
• Boiling Point: 318.8 °C at 760 mmHg
• PKA: 1.69±0.10(Predicted)
• Flash Point: 146.6 °C
• PSA: 63.32000
• Density: 1.392 g/cm³
• LogP: 2.12470
• Storage Temp.: Store under inert gas
• Sensitive.: Air Sensitive

Purity/Quality:

99%, ^*data from raw suppliers

DL-2-Chlorophenylglycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AMINO-(2-CHLORO-PHENYL)-ACETIC ACID

There total 7 articles about AMINO-(2-CHLORO-PHENYL)-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

sodium cyanide (143-33-9,25596-52-5) + 2-chloro-benzaldehyde (89-98-5) → 2-amino-(2-chlorophenyl)ethanoic acid (86169-24-6,141196-64-7,141315-50-6,88744-36-9)

Guidance literature:

sodium cyanide; 2-chloro-benzaldehyde; With ammonium bicarbonate; In methanol; water; at 65 - 70 ℃; for 5h;

With sodium hydroxide; In methanol; water; at 120 ℃; for 4h;

With sulfuric acid; In methanol; water; pH=7 - 8;

Reference yield:

5-(2-chlorophenyl)imidazolidine-2,4-dione (103029-09-0) → 2-amino-(2-chlorophenyl)ethanoic acid (86169-24-6,141196-64-7,141315-50-6,88744-36-9)

Guidance literature:

With sodium hydroxide;

DOI:10.1039/jr9620001440

Reference yield:

N-(o-chlorophenyl)hydantoin (187243-26-1) → 2-amino-(2-chlorophenyl)ethanoic acid (86169-24-6,141196-64-7,141315-50-6,88744-36-9)

Guidance literature:

N-(o-chlorophenyl)hydantoin; With sodium hydroxide; In water; at 101 - 175 ℃; under 3750.38 - 7500.75 Torr; Large scale;

With sulfuric acid; In water; at 35 - 100 ℃; pH=6-6.3; Large scale;

upstream raw materials:

ortho-chlorophenylmalonic acid

5-(2-chlorophenyl)imidazolidine-2,4-dione

sodium cyanide

2-chloro-benzaldehyde

Downstream raw materials:

2-chloro-benzaldehyde

α-bromo-2-chlorophenyl acetic acid

2-(2-chlorophenyl)glycine methyl ester hydrochloride

S(+)-chlorophenylglycine-d-camphoric sulfonic acid

Refernces

• 1、 -. "Preparation method for D, L-phenylglycine and analogue thereof". Paragraph 0049; 0050. . Retrieved 2017/03/17.
• 2、 Kobow,Sprung,Schulz. "Synthesis of some chlorosubstituted DL-phenylamino acid alkylester hydrochlorides". . p. 529 - 530. Retrieved 2007/10/02.