2-naphthylacetic acid benzyl ester

Base Information

• Chemical Name: 2-naphthylacetic acid benzyl ester
• CAS No.: 53342-32-8
• Molecular Formula: C₁₉H₁₆O₂
• Molecular Weight: 276.335
• Mol file: 53342-32-8.mol

Synonyms:2-naphthylacetic acid benzyl ester

Chemical Property of 2-naphthylacetic acid benzyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-naphthylacetic acid benzyl ester

There total 6 articles about 2-naphthylacetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl bromide (100-39-0) + 4S-(-)-isopropyl-2-oxazolidinone (40482-44-8) + 2-naphthylacetic acid (581-96-4) → 2-naphthylacetic acid benzyl ester (53342-32-8) + (2-methyl-naphthalen-1-yl)-acetic acid (85-08-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In naphth-1-yl acetic acid; ethyl acetate; acetonitrile;

Reference yield: 100.0%

benzyl bromide (100-39-0) + 2-naphthylacetic acid (581-96-4) → 2-naphthylacetic acid benzyl ester (53342-32-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 3h;

DOI:10.1021/jm000446q

Reference yield: 76.0%

2-bromomethylnaphthyl bromide (939-26-4) + benzyl alcohol (100-51-6,185532-71-2) + molybdenum hexacarbonyl (13939-06-5,199620-15-0) → 2-naphthylacetic acid benzyl ester (53342-32-8)

Guidance literature:

With C₃₅H₂₀F₃₄NO₃^(1-)*Pd⁽²⁺⁾*Cl^(1-); N-ethyl-N,N-diisopropylamine; In neat (no solvent); at 150 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.tet.2014.09.065

upstream raw materials:

2-naphthylacetyl chloride

benzyl alcohol

benzyl bromide

2-naphthylacetic acid

Downstream raw materials:

2,2-dimethyl-(2-naphthyl)acetic acid benzyl ester

C₂₇H₂₁N₃O₂

benzyl 2-diazo-2-(naphthalen-2-yl)acetate

Difluoro-naphthalen-2-yl-acetic acid benzyl ester

Refernces

• 1、 Ang, Wei Jie,Lo, Lee-Chiang,Lam, Yulin. "Expedient carbonylation of aryl halides in aqueous or neat condition". . p. 8545 - 8558. Retrieved 2014/12/11.
• 2、 -. "Src family SH2 domain inhibitors". . . Retrieved 2008/06/13.