Adenosine 5'-triphosphate disodium salt

Base Information

• Chemical Name: Adenosine 5'-triphosphate disodium salt
• CAS No.: 987-65-5
• Molecular Formula: C₁₀H₁₄N₅O₁₃P₃*2Na
• Molecular Weight: 551.148
• Hs Code.: 29389090
• European Community (EC) Number: 213-579-1,685-285-5,686-884-4
• NCI Thesaurus Code: C83607
• Mol file: 987-65-5.mol

Synonyms:987-65-5;Disodium ATP;ATP disodium salt;Adenosine 5'-triphosphate disodium salt;Disodium adenosine triphosphate;Adenosine triphosphate disodium;ATP (Adenosine-Triphosphate);Triphosadenine;C10H14N5Na2O13P3;Disodium adenosine 5'-triphosphate;Adenosine triphosphate disodium salt;Adenosine-5'-triphosphate disodium salt;34369-07-8;51963-61-2;Adenosine 5'-Triphosphate, disodium salt;C10-H16-N5-O13-P3.2Na;Adenosine 5'- (tetrahydrogen triphosphate), disodium salt;Adenosin 5'-(tetrahidrogen trifosfato), sal de sodio (1:2);Adenosine 5'-(tetrahydrogen triphosphate), disodium salt, hydrate;5'-ATP 2Na;TTWYZDPBDWHJOR-IDIVVRGQSA-L;AKOS024306765;AKOS037643303;AC-32152;AS-13244;A0157;Adenosine 5-triphosphate disodium salt dihydrate;A845904;1174161-60-4;sodium (((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)triphosphoric acid

Chemical Property of Adenosine 5'-triphosphate disodium salt

Chemical Property:

• Appearance/Colour: Solid.
• Vapor Pressure: 0.1Pa at 20-50℃
• Melting Point: 188-190oC
• Boiling Point: 951.4 °C at 760 mmHg
• Flash Point: 529.2 °C
• PSA: 314.22000
• Density: 2.63g/cm3
• LogP: -0.17140
• Storage Temp.: 2-8°C
• Solubility.: H2O: 50 mg/mL
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 8
• Exact Mass: 550.95963508
• Heavy Atom Count: 33
• Complexity: 783

Purity/Quality:

98% ^*data from raw suppliers

ATPDisodiumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)([O-])OP(=O)([O-])OP(=O)(O)O)O)O)N.[Na+].[Na+]
• Isomeric SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)([O-])OP(=O)(O)O)O)O)N.[Na+].[Na+]
• Recent NIPH Clinical Trials: The clinical evaluation of the Kampo therapy for Meniere disease.
• Uses: A metabolite of Adenosine (A280400), a multifunctional nucleoside triphosphate used in cells as a coenzyme of intracellular energy transfer. It transports chemical energy within cells for metabolism. ATP Disodium Salt is used in the synthetic preparation of ribose-modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands. Adenosine 5'-triphosphate disodium salt is a disodium salt form of adenosine-triphosphate which is a multifunctional nucleoside triphosphate.ATP (Adenosine-Triphosphate) transports chemical energy within cells for metabolism. ATP (Adenosine-Triphosphate) is produced by photophosphoryla. In biochemical research. To inhibit enzymatic browning of raw edible plant materials, such as sliced apples, potatoes, etc.

Technology Process of Adenosine 5'-triphosphate disodium salt

There total 13 articles about Adenosine 5'-triphosphate disodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

adenosine 5′-phosphoropiperidate triethylammonium salt (1577254-51-3) → adenosine 5'-triphosphate (606-67-7,987-65-5,4691-96-7,15237-44-2,20978-32-9,71997-34-7,71997-37-0,71997-53-0,71997-56-3)

Guidance literature:

adenosine 5′-phosphoropiperidate triethylammonium salt; With 4,5-dicyano-1H-imidazole; tris(tetra-n-butylammonium) hydrogen pyrophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 6h; Inert atmosphere;

With sodium acetate; In ethanol; water; Further stages; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.02.031

Reference yield: 58.0%

C54H54N21O42P9(12-) → adenosine 5'-triphosphate (606-67-7,987-65-5,4691-96-7,15237-44-2,20978-32-9,71997-34-7,71997-37-0,71997-53-0,71997-56-3)

Guidance literature:

C₅₄H₅₄N₂₁O₄₂P₉^(12-); With ammonium hydroxide; at 50 ℃; Sealed tube;

In methanol; water; at 50 ℃; for 5h; Sealed tube;

Sealed tube;

DOI:10.1002/ejoc.202100544

Reference yield:

adenosine 5'-trimetaphosphate (53355-60-5) → adenosine 5'-triphosphate (606-67-7,987-65-5,4691-96-7,15237-44-2,20978-32-9,71997-34-7,71997-37-0,71997-53-0,71997-56-3) + adenosine-5′-diphosphate trisodium salt (1172-42-5,2092-65-1,16178-48-6,20398-34-9,71997-33-6,71997-36-9,71997-52-9,71997-55-2)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1039/c39910001276

upstream raw materials:

adenosine 5'-trimetaphosphate

C₁₀H₁₂Cl₂N₅O₅P

adenosine

adenosine (5'-phosphoro-1-piperidinide)

Downstream raw materials:

adenosine diphosphate disodium salt

5'-adenosine monophosphate

adenosine 5'-diphosphate

Refernces

• 1、 Appy, Lucie,Peyrottes, Suzanne,Roy, Béatrice. "Supported Synthesis of Adenosine Nucleotides and Derivatives on a Benzene-Centered Tripodal Soluble Support". . . Retrieved 2021/06/23.
• 2、 Sun, Qi,Gong, Shanshan,Sun, Jian,Liu, Si,Xiao, Qiang,Pu, Shouzhi. "A P(V)-N activation strategy for the synthesis of nucleoside polyphosphates". . p. 8417 - 8426. Retrieved 2013/09/24.