allyl 4-(dimethylamino)benzoate

Base Information

• Chemical Name: allyl 4-(dimethylamino)benzoate
• CAS No.: 22636-68-6
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.257
• Mol file: 22636-68-6.mol

Synonyms:allyl 4-(dimethylamino)benzoate

Chemical Property of allyl 4-(dimethylamino)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of allyl 4-(dimethylamino)benzoate

There total 4 articles about allyl 4-(dimethylamino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

p-N,N-dimethylaminobenzoic acid (619-84-1) + allyl alcohol (107-18-6) → allyl 4-(dimethylamino)benzoate (22636-68-6)

Guidance literature:

p-N,N-dimethylaminobenzoic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.25h;

allyl alcohol; With dmap; In dichloromethane; at 20 ℃;

DOI:10.1002/chem.202002542

Reference yield:

p-N,N-dimethylaminobenzoic acid (619-84-1) → allyl 4-(dimethylamino)benzoate (22636-68-6)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / CH₂Cl₂ / 0.08 h

2: pyridine / CH₂Cl₂ / 2 h

With pyridine; oxalyl dichloride; In dichloromethane;

DOI:10.1021/ja00073a028

Reference yield:

4-(dimethylamino)benzoyl chloride (4755-50-4) + allyl alcohol (107-18-6) → allyl 4-(dimethylamino)benzoate (22636-68-6)

Guidance literature:

With pyridine; In dichloromethane; for 2h; Yield given;

DOI:10.1021/ja00073a028

upstream raw materials:

4-(dimethylamino)benzoyl chloride

allyl alcohol

p-N,N-dimethylaminobenzoic acid

allyl bromide

Downstream raw materials:

p-N,N-dimethylaminobenzoic acid

Refernces

• 1、 Tu, Hai-Yong,Wang, Fang,Huo, Liping,Li, Yuanbo,Zhu, Shengqing,Zhao, Xian,Li, Huan,Qing, Feng-Ling,Chu, Lingling. "Enantioselective Three-Component Fluoroalkylarylation of Unactivated Olefins through Nickel-Catalyzed Cross-Electrophile Coupling". supporting information. p. 9604 - 9611. Retrieved 2020/07/14.
• 2、 Deming, Timothy J.,Novak, Bruce M.. "Mechanistic studies on the nickel-catalyzed polymerization of isocyanides". . p. 9101 - 9111. Retrieved 2007/10/02.